7-chloro-5-(2-fluorophenyl)-N-hydroxy-alpha-nitro-3H-1,4-benzodiazepine-2-methanimine 4-oxide

Base Information

• Chemical Name: 7-chloro-5-(2-fluorophenyl)-N-hydroxy-alpha-nitro-3H-1,4-benzodiazepine-2-methanimine 4-oxide
• CAS No.: 76488-36-3
• Molecular Formula: C₁₆H₁₀ClFN₄O₄
• Molecular Weight: 376.731

Synonyms:7-chloro-5-(2-fluorophenyl)-N-hydroxy-alpha-nitro-3H-1,4-benzodiazepine-2-methanimine 4-oxide

Chemical Property of 7-chloro-5-(2-fluorophenyl)-N-hydroxy-alpha-nitro-3H-1,4-benzodiazepine-2-methanimine 4-oxide

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Technology Process of 7-chloro-5-(2-fluorophenyl)-N-hydroxy-alpha-nitro-3H-1,4-benzodiazepine-2-methanimine 4-oxide

There total 1 articles about 7-chloro-5-(2-fluorophenyl)-N-hydroxy-alpha-nitro-3H-1,4-benzodiazepine-2-methanimine 4-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

7-chloro-5-(2-fluorophenyl)-2-nitromethylene-2H-1,3-dihydro-1,4-benzodiazepine 4-oxide (60656-76-0) → 7-chloro-5-(2-fluorophenyl)-N-hydroxy-alpha-nitro-3H-1,4-benzodiazepine-2-methanimine 4-oxide (76488-36-3)

Guidance literature:

With sodium nitrite; In acetic acid; 1) 70 deg C, 10 min.; 2) room temp., 0.5 h;

DOI:10.1002/jhet.5570200313

Reference yield: 87.0%

7-chloro-5-(2-fluorophenyl)-N-hydroxy-alpha-nitro-3H-1,4-benzodiazepine-2-methanimine 4-oxide (76488-36-3) → 7-chloro-5-(2-fluorophenyl)-3H-1,4-benzodiazepine-2-N'-hydroxycarboximidamide 4-oxide (76488-10-3)

Guidance literature:

With ammonia; In methanol; Ambient temperature; overnight;

DOI:10.1002/jhet.5570200313

Reference yield: 86.0%

morpholine (110-91-8,99108-56-2) + 7-chloro-5-(2-fluorophenyl)-N-hydroxy-alpha-nitro-3H-1,4-benzodiazepine-2-methanimine 4-oxide (76488-36-3) → 7-chloro-5-(2-fluorophenyl)-2-<4-<(hydroxyimino)methyl>morpholinyl>-3H-1,4-benzodiazepine 4-oxide (76488-19-2)

Guidance literature:

In tetrahydrofuran; Ambient temperature;

DOI:10.1002/jhet.5570200313

upstream raw materials:

7-chloro-5-(2-fluorophenyl)-2-nitromethylene-2H-1,3-dihydro-1,4-benzodiazepine 4-oxide

Downstream raw materials:

7-chloro-5-(2-fluorophenyl)-N-methoxy-alpha-nitro-3H-1,4-benzodiazepine-2-methanimine 4-oxide

7-chloro-5-(2-fluorophenyl)-N-<(4-methoxy)butoxy>-alpha-nitro-3H-1,4-benzodiazepine-2-methanimine 4-oxide

7-chloro-5-(2-fluorophenyl)-2-<4-<(hydroxyimino)methyl>morpholinyl>-3H-1,4-benzodiazepine 4-oxide

7-chloro-5-(2-fluorophenyl)-2-methoxy-3H-1,4-benzodiazepine 4-oxide

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