7-CHLORO-1,3DIHYDRO-5-FLUOROPHENYL-2-NITRO-METHYLENE-2H-1,4-BENZODIAZEPINE-4-OXIDE

Base Information

• Chemical Name: 7-CHLORO-1,3DIHYDRO-5-FLUOROPHENYL-2-NITRO-METHYLENE-2H-1,4-BENZODIAZEPINE-4-OXIDE
• CAS No.: 60656-76-0
• Molecular Formula: C16H11ClFN3O3
• Molecular Weight: 347.73
• Mol file: 60656-76-0.mol

Synonyms:7-CHLORO-1,3DIHYDRO-5-FLUOROPHENYL-2-NITRO-METHYLENE-2H-1,4-BENZODIAZEPINE-4-OXIDE;

Chemical Property of 7-CHLORO-1,3DIHYDRO-5-FLUOROPHENYL-2-NITRO-METHYLENE-2H-1,4-BENZODIAZEPINE-4-OXIDE

Chemical Property:

• Melting Point: 240-243 °C(Solv: N,N-dimethylformamide (68-12-2); water (7732-18-5))
• Boiling Point: 539.7±60.0 °C(Predicted)
• PKA: -1.18±0.20(Predicted)
• PSA: 77.81000
• Density: 1.49±0.1 g/cm3(Predicted)
• LogP: 4.22350

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 7-Chloro-5-(2-fluorophenyl)-2,3-dihydro-2-(nitromethylene)-1H-1,4-benzodiazepine 4-Oxide is the synthetic precursor of Midazolam (M343000), an anesthetic, anticonvulsant, sedative and hypotic agent.

Technology Process of 7-CHLORO-1,3DIHYDRO-5-FLUOROPHENYL-2-NITRO-METHYLENE-2H-1,4-BENZODIAZEPINE-4-OXIDE

There total 1 articles about 7-CHLORO-1,3DIHYDRO-5-FLUOROPHENYL-2-NITRO-METHYLENE-2H-1,4-BENZODIAZEPINE-4-OXIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 7-chloro-5-(2-fluorophenyl)-2-nitromethylene-2H-1,3-dihydro-1,4-benzodiazepine 4-oxide (60656-76-0)

Guidance literature:

aus Chlormethyl-Verb. 3b + Me-NO2;

Reference yield: 79.0%

7-chloro-5-(2-fluorophenyl)-2-nitromethylene-2H-1,3-dihydro-1,4-benzodiazepine 4-oxide (60656-76-0) → 7-chloro-5-(2-fluorophenyl)-N-hydroxy-alpha-nitro-3H-1,4-benzodiazepine-2-methanimine 4-oxide (76488-36-3)

Guidance literature:

With sodium nitrite; In acetic acid; 1) 70 deg C, 10 min.; 2) room temp., 0.5 h;

DOI:10.1002/jhet.5570200313

Reference yield:

7-chloro-5-(2-fluorophenyl)-2-nitromethylene-2H-1,3-dihydro-1,4-benzodiazepine 4-oxide (60656-76-0) → 7-Chloro-5-(2-fluorophenyl)-N-hydroxy-α-nitro-3 H-1,4-benzodiazepine-2-methanimine 4-oxide

Guidance literature:

With sodium nitrite; In acetic acid;

Downstream raw materials:

7-chloro-5-(2-fluorophenyl)-N-hydroxy-alpha-nitro-3H-1,4-benzodiazepine-2-methanimine 4-oxide

7-chloro-5-(2-fluorophenyl)-2-methoxy-3H-1,4-benzodiazepine 4-oxide

7-chloro-5-(2-fluorophenyl)-3H-1,4-benzodiazepine-2-N'-hydroxycarboximidamide 4-oxide

7-chloro-5-(2-fluorophenyl)-N-hydroxy-3H-1,4-benzodiazepine-2-carboximidothioic acid methyl ester 4-oxide

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