3-[(4-Methoxy-phenyl)-diphenyl-methoxy]-2-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-propionaldehyde

Base Information

• Chemical Name: 3-[(4-Methoxy-phenyl)-diphenyl-methoxy]-2-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-propionaldehyde
• CAS No.: 100683-69-0
• Molecular Formula: C₄₉H₄₃N₅O₆
• Molecular Weight: 797.91

Synonyms:3-[(4-Methoxy-phenyl)-diphenyl-methoxy]-2-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-propionaldehyde

Chemical Property of 3-[(4-Methoxy-phenyl)-diphenyl-methoxy]-2-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-propionaldehyde

Chemical Property:

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Technology Process of 3-[(4-Methoxy-phenyl)-diphenyl-methoxy]-2-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-propionaldehyde

There total 3 articles about 3-[(4-Methoxy-phenyl)-diphenyl-methoxy]-2-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-propionaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

9-[({1-hydroxy-3-[(4-methoxyphenyl)-diphenylmethoxy]propan-2-yl}oxy)methyl]-2-{[(4-methoxyphenyl)diphenylmethyl]amino}-6,9-dihydro-1H-purin-6-one (88110-86-5) → 3-[(4-Methoxy-phenyl)-diphenyl-methoxy]-2-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-propionaldehyde (100683-69-0)

Guidance literature:

With methylphosphonic acid; dicyclohexyl-carbodiimide; In dimethyl sulfoxide; 1.) 18 deg C, 5 h, 2.) RT, 16 h;

DOI:10.1021/jm00155a015

Reference yield:

ganciclovir (82410-32-0) → 3-[(4-Methoxy-phenyl)-diphenyl-methoxy]-2-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-propionaldehyde (100683-69-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 43 percent / triethylamine, 4-(dimethylamino)pyridine / dimethylformamide / 2 h / 40 °C

2: 9.5 g / dicyclohexylcarbodiimide, methylphosphonic acid / dimethylsulfoxide / 1.) 18 deg C, 5 h, 2.) RT, 16 h

With dmap; methylphosphonic acid; triethylamine; dicyclohexyl-carbodiimide; In dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1021/jm00155a015

Reference yield:

mono-4-methoxytrityl chloride (14470-28-1) → 3-[(4-Methoxy-phenyl)-diphenyl-methoxy]-2-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-propionaldehyde (100683-69-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 43 percent / triethylamine, 4-(dimethylamino)pyridine / dimethylformamide / 2 h / 40 °C

2: 9.5 g / dicyclohexylcarbodiimide, methylphosphonic acid / dimethylsulfoxide / 1.) 18 deg C, 5 h, 2.) RT, 16 h

With dmap; methylphosphonic acid; triethylamine; dicyclohexyl-carbodiimide; In dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1021/jm00155a015

upstream raw materials:

9-[({1-hydroxy-3-[(4-methoxyphenyl)-diphenylmethoxy]propan-2-yl}oxy)methyl]-2-{[(4-methoxyphenyl)diphenylmethyl]amino}-6,9-dihydro-1H-purin-6-one

ganciclovir

mono-4-methoxytrityl chloride

Downstream raw materials:

N²-(p-anisyldiphenylmethyl)-9-<<<4-(p-anisyldiphenylmethoxy)-1(E)-(diphenoxyphosphinyl)but-1-en-3-yl>oxy>-methyl>guanine

N²-(p-anisyldiphenylmethyl)-9-<<4-(p-anisyldiphenylmethoxy)-1--3-butoxy>methyl>guanine

N²-(p-anisyldiphenylmethyl)-9-<<4-(p-anisyldiphenylmethoxy)-1-(diphenoxyphosphinyl)-3-butoxy>-methyl>guanine

9-<<1--4-hydroxy-3-butoxy>-methyl>guanine

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