88110-86-5

Basic information

• Product Name: 9H-Purin-6-amine, 9-[[(2-hydroxy-2-oxido-1,3,2-dioxaphosphorinan-5-yl)oxy]methyl]-
• Synonyms: 9H-Purin-6-amine, 9-(((2-hydroxy-2-oxido-1,3,2-dioxaphosphorinan-5-yl)oxy)methyl)-
• CAS NO: 88110-86-5
• Molecular Formula: C₉H₁₂N₅O₅P
• Molecular Weight: 799.926
• Mol File: 88110-86-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 576.7°Cat760mmHg
• Flash Point: 302.6°C
• Density: 2.03g/cm³
• CAS DataBase Reference: 9H-Purin-6-amine, 9-[[(2-hydroxy-2-oxido-1,3,2-dioxaphosphorinan-5-yl)oxy]methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 9H-Purin-6-amine, 9-[[(2-hydroxy-2-oxido-1,3,2-dioxaphosphorinan-5-yl)oxy]methyl]-(88110-86-5)
• EPA Substance Registry System: 9H-Purin-6-amine, 9-[[(2-hydroxy-2-oxido-1,3,2-dioxaphosphorinan-5-yl)oxy]methyl]-(88110-86-5)

Safety Data

• Hazardous Substances Data: 88110-86-5(Hazardous Substances Data)

Upstream product

• 82410-32-0 ganciclovir 
• 14470-28-1 mono-4-methoxytrityl chloride 
• 18602-85-2 2,6,9-tris(trimethylsilyl)guanine 
• 82410-31-9 9-<<2-(benzyloxy)-1-<(benzyloxy)methyl>ethoxy>methyl>guanine 
• 73-40-5 2-amino-1,9-dihydro-6H-purin-6-one 

Downstream Products

• 269716-58-7 N²-(p-anisyldiphenylmethyl)-9-[[1-(p-anisyldiphenylmethoxy)-3-fluoro-2-propoxy]methyl]guanine 
• 100683-70-3 N²-(p-anisyldiphenylmethyl)-9-<<4-(p-anisyldiphenylmethoxy)-1--3-butoxy>methyl>guanine 
• 100701-09-5 N²-(p-anisyldiphenylmethyl)-9-<<<4-(p-anisyldiphenylmethoxy)-1(E)-(diphenoxyphosphinyl)but-1-en-3-yl>oxy>-methyl>guanine 
• 100701-10-8 N²-(p-anisyldiphenylmethyl)-9-<<4-(p-anisyldiphenylmethoxy)-1-(diphenoxyphosphinyl)-3-butoxy>-methyl>guanine 
• 103024-81-3 N²-(p-anisyldiphenylmethyl)-9-<<1-(p-anisyldiphenylmethoxy)-3-azido-2-propoxy>methyl>guanine 
• 103067-94-3 9-<<3-amino-1-(p-anisyldiphenylmethoxy)-2-propoxy>methyl>-N²-(p-anisyldiphenylmethyl)guanine 
• 100683-71-4 9-<<1--4-hydroxy-3-butoxy>-methyl>guanine 
• 104880-60-6 3-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)-4-hydroxybutylphosphonic acid 
• 103024-80-2 N²-(p-anisyldiphenylmethyl)-9-<<(p-anisyldiphenylmethoxy)-3-(p-toluenesulfonyloxy)-2-propoxy>methyl>-guanine 
• 109082-87-3 Hexadecanoic acid 3-[(4-methoxy-phenyl)-diphenyl-methoxy]-2-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-propyl ester 
• 109082-86-2 Adamantane-1-carboxylic acid 3-[(4-methoxy-phenyl)-diphenyl-methoxy]-2-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-propyl ester 
• 100683-69-0 3-[(4-Methoxy-phenyl)-diphenyl-methoxy]-2-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-propionaldehyde 

Relevant articles and documents

Efficient synthesis of 9-(4-[18F]fluoro-3-hydroxymethylbutyl)guanine ([18F]FHBG) and 9-[(3-[18F]fluoro-1-hydroxy-2-propoxy)methyl]guanine ([18F]FHPG)

A new, high radiochemical yield synthesis of [18F]FHBG and [18F]FHPG, the most popular imaging agents currently in use for monitoring gene therapy using positron emission tomography (PET), is reported in this work. Protection of sens

An Improved Total Synthesis of PET HSV-tk Gene Expression Imaging Agent 9-[(3-[18F]Fluoro-1-hydroxy-2-propoxy)methyl]guanine ([ 18F]FHPG)

An improved total synthesis of [18F]FHPG starting from 1,3-dibenzyloxy-2-propanol and guanine has been developed. [18F]FHPG was prepared by nucleophilic substitution of the appropriate precursor with [18F]KF/ Kryptofix 2.2.2 followed by a quick deprotection reaction and purification with a simplified Silica Sep-Pak solid-phase extraction (SPE) method in 10-15% radiochemical yield, and 70 min synthesis time from end of bombardment (EOB).

An Improved Total Synthesis of PET HSV-tk Gene Reporter Probe [18F]FHPG

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