5-(5-bromo-2-chlorophenyl)-1H-tetrazole

Base Information

• Chemical Name: 5-(5-bromo-2-chlorophenyl)-1H-tetrazole
• CAS No.: 1262519-03-8
• Molecular Formula: C₇H₄BrClN₄
• Molecular Weight: 259.493
• Mol file: 1262519-03-8.mol

Synonyms:5-(5-bromo-2-chlorophenyl)-1H-tetrazole

Chemical Property of 5-(5-bromo-2-chlorophenyl)-1H-tetrazole

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 5-(5-bromo-2-chlorophenyl)-1H-tetrazole

There total 1 articles about 5-(5-bromo-2-chlorophenyl)-1H-tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

5-bromo-2-chlorobenzonitrile (57381-44-9) → 5-(5-bromo-2-chlorophenyl)-1H-tetrazole (1262519-03-8)

Guidance literature:

With trimethylsilylazide; di(n-butyl)tin oxide; In toluene; for 48h; Reflux;

DOI:10.1021/jm101014v

Reference yield: 56.0%

5-formylfurane-2-boronic acid (27329-70-0) + 5-(5-bromo-2-chlorophenyl)-1H-tetrazole (1262519-03-8) → 5-(4-chloro-3-(1H-tetrazol-5-yl)phenyl)furan-2-carbaldehyde (1262519-12-9)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In 1,2-dimethoxyethane; ethanol; water; at 60 ℃; for 20h; Inert atmosphere;

DOI:10.1021/jm101014v

Reference yield:

5-formylfurane-2-boronic acid (27329-70-0) + 5-(5-bromo-2-chlorophenyl)-1H-tetrazole (1262519-03-8) → 5-((5-(4-chloro-3-(1H-tetrazol-5-yl)phenyl)furan-2-yl)methylene)-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-4-one (1286670-38-9)

Guidance literature:

Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,2-dimethoxyethane; ethanol; water / 20 h / 60 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / toluene / 16 h / Reflux

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; N-ethyl-N,N-diisopropylamine; In 1,2-dimethoxyethane; ethanol; water; toluene; 1: Suzuki coupling / 2: Knoevenagel condensation;

DOI:10.1021/jm101014v

upstream raw materials:

5-bromo-2-chlorobenzonitrile

Downstream raw materials:

5-((5-(4-chloro-3-(1H-tetrazol-5-yl)phenyl)furan-2-yl)methylene)-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-4-one

5-(4-chloro-3-(1H-tetrazol-5-yl)phenyl)furan-2-carbaldehyde

Refernces