(E)-2-(3,4,5-trimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxo-2-butenonitrile

Base Information

• Chemical Name: (E)-2-(3,4,5-trimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxo-2-butenonitrile
• CAS No.: 138037-36-2
• Molecular Formula: C₂₀H₁₇NO₆
• Molecular Weight: 367.358
• Mol file: 138037-36-2.mol

Synonyms:(E)-2-(3,4,5-trimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxo-2-butenonitrile

Chemical Property of (E)-2-(3,4,5-trimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxo-2-butenonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2-(3,4,5-trimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxo-2-butenonitrile

There total 2 articles about (E)-2-(3,4,5-trimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxo-2-butenonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.4%

(Z)-2-(3,4,5-trimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxo-2-butenonitrile (138037-37-3) → (E)-2-(3,4,5-trimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxo-2-butenonitrile (138037-36-2)

Guidance literature:

In ethyl acetate; for 24h; Irradiation;

DOI:10.1016/S0040-4020(01)85506-X

Reference yield:

4-(3,4-methylenedioxyphenyl)-4-oxo-2-(3,4,5-trimethoxyphenyl)butyronitrile (88775-24-0) → (E)-2-(3,4,5-trimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxo-2-butenonitrile (138037-36-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 44.4 percent / DDQ / benzene / 18.5 h / Heating; in the dark

2: 81.4 percent / ethyl acetate / 24 h / Irradiation

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In ethyl acetate; benzene;

DOI:10.1016/S0040-4020(01)85506-X

Reference yield: 80.0%

(E)-2-(3,4,5-trimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxo-2-butenonitrile (138037-36-2) → (Z)-2-(3,4,5-trimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxo-2-butenoic acid (88775-49-9)

Guidance literature:

With sodium hydroxide; In methanol; water; for 0.5h; Heating;

DOI:10.1016/S0040-4020(01)85506-X

upstream raw materials:

(Z)-2-(3,4,5-trimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxo-2-butenonitrile

4-(3,4-methylenedioxyphenyl)-4-oxo-2-(3,4,5-trimethoxyphenyl)butyronitrile

Downstream raw materials:

1,t-2-bis(3,4,5-trimethoxyphenyl)-c-3,c-4-bis(3,4-methylenedioxybenzoyl)-r-1,c-2-cyclobutanedinitrile

1,t-2-bis(3,4,5-trimethoxyphenyl)-c-3,t-4-bis(3,4-methylenedioxybenzoyl)-r-1,c-2-cyclobutanedinitrile

(Z)-2-(3,4,5-trimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxo-2-butenonitrile

(Z)-2-(3,4,5-trimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxo-2-butenoic acid