3(2H)-Benzofuranone, 6-Bromo-

Base Information

• Chemical Name: 3(2H)-Benzofuranone, 6-Bromo-
• CAS No.: 201809-69-0
• Molecular Formula: C8H5BrO2
• Molecular Weight: 213.03
• Hs Code.: 2932999099
• Mol file: 201809-69-0.mol

Synonyms:6-Bromobenzofuran-3-one;6-bromobenzofuran-3(2H)-one;6-Bromo-3-Benzofuranone;6-Bromo-3(2H)-benzofuranone;6-Bromo-2-hydrobenzo[b]furan-3-one;

Chemical Property of 3(2H)-Benzofuranone, 6-Bromo-

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.681
• Boiling Point: 319.5 °C at 760 mmHg
• Flash Point: 147 °C
• PSA: 26.30000
• Density: 1.742 g/cm³
• LogP: 2.02420
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

6-Bromobenzofuran-3(2H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Bromobenzofuran-3(2H)-one is a useful reactant for the preparation of tricyclic sulfones as RORγ modulators.

Technology Process of 3(2H)-Benzofuranone, 6-Bromo-

There total 1 articles about 3(2H)-Benzofuranone, 6-Bromo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4'-bromo-2'-hydroxyacetophenone (30186-18-6) → 6-bromo-2,3-dihydro-1-benzofuran-3-one (201809-69-0)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N,N-trimethylbenzenemethanaminium dichloroiodate / methanol; 1,2-dichloro-ethane / 4 h / 70 °C / Inert atmosphere

2: triethylamine / acetonitrile / 2 h

With N,N,N-trimethylbenzenemethanaminium dichloroiodate; triethylamine; In methanol; 1,2-dichloro-ethane; acetonitrile;

Reference yield: 95.0%

6-bromo-2,3-dihydro-1-benzofuran-3-one (201809-69-0) + benzaldehyde (100-52-7) → (Z)-2-Benzylidene-6-bromobenzofuran-3(2H)-one

Guidance literature:

With aluminum oxide; In dichloromethane; at 20 ℃;

DOI:10.1039/c8ob01558a

Reference yield: 92.0%

6-bromo-2,3-dihydro-1-benzofuran-3-one (201809-69-0) → (rac)-6-bromo-2,3-dihydrobenzofuran-3-ol (1392072-52-4)

Guidance literature:

6-bromo-2,3-dihydro-1-benzofuran-3-one; With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; for 2h; Inert atmosphere;

With ammonium chloride; In methanol;

upstream raw materials:

4'-bromo-2'-hydroxyacetophenone

Downstream raw materials:

(rac)-6-bromo-2,3-dihydrobenzofuran-3-ol