Technology Process of 4-{1-[(S)-4-(2,3-dihydro-benzo[1,4]dioxin-2-yl)-benzyl]-azetidin-3-yl}-benzoic acid methyl ester
There total 14 articles about 4-{1-[(S)-4-(2,3-dihydro-benzo[1,4]dioxin-2-yl)-benzyl]-azetidin-3-yl}-benzoic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(S)-4-(2,3-dihydro-benzo[1,4]dioxin-2-yl)-benzaldehyde; 4-azetidin-3-yl-benzoic acid methyl ester hydrochloride;
With
N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl acetamide;
at 25 ℃;
for 0.25h;
With
sodium tris(acetoxy)borohydride;
In
N,N-dimethyl acetamide;
at 25 ℃;
for 16h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / acetonitrile / 0.75 h / 20 °C / Inert atmosphere
1.2: 0.83 h / 20 - 25 °C / Inert atmosphere
2.1: triethylamine; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; (R,R)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine / acetonitrile / 1 h / 20 °C
2.2: 0.5 h / 5 - 15 °C
3.1: copper(l) iodide; 1,10-Phenanthroline / 1,4-dioxane / Inert atmosphere; Reflux
4.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 2.5 h / 0 - 20 °C
5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 0.25 h / 25 °C
5.2: 16 h / 25 °C
With
copper(l) iodide; 1,10-Phenanthroline; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; diisobutylaluminium hydride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; (R,R)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine;
In
tetrahydrofuran; 1,4-dioxane; N,N-dimethyl acetamide; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / acetonitrile / 0.75 h / 20 °C / Inert atmosphere
1.2: 0.83 h / 20 - 25 °C / Inert atmosphere
2.1: triethylamine; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; (R,R)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine / acetonitrile / 1 h / 20 °C
2.2: 0.5 h / 5 - 15 °C
3.1: copper(l) iodide; 1,10-Phenanthroline / 1,4-dioxane / Inert atmosphere; Reflux
4.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 2.5 h / 0 - 20 °C
5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 0.25 h / 25 °C
5.2: 16 h / 25 °C
With
copper(l) iodide; 1,10-Phenanthroline; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; diisobutylaluminium hydride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; (R,R)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine;
In
tetrahydrofuran; 1,4-dioxane; N,N-dimethyl acetamide; toluene; acetonitrile;
![(S)-4-(2,3-dihydro-benzo[1,4]dioxin-2-yl)-benzaldehyde](/Databaselist/images/loading.webp)
