Norfloxacinehydrochloride

Base Information

• Chemical Name: Norfloxacinehydrochloride
• CAS No.: 68077-27-0
• Molecular Formula: C16H18FN3O3·ClH
• Molecular Weight: 355.797
• Hs Code.: 2933499090

Synonyms:3-Quinolinecarboxylicacid, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-, monohydrochloride (9CI);1-Ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydro-3-quinolinecarboxylic acid;3-Quinolinecarboxylicacid, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-, hydrochloride(1:1);Floxacin;

Chemical Property of Norfloxacinehydrochloride

Chemical Property:

• PSA: 74.57000
• LogP: 1.66210

Purity/Quality:

99% ^*data from raw suppliers

Norfloxacin(hydrochloride) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): FC
• Hazard Codes: F,C
• Statements: 11-34
• Safety Statements: 16-26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Norfloxacinehydrochloride

There total 14 articles about Norfloxacinehydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

7-{4-[(tert-butoxy)carbonyl]piperazin-1-yl}-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (127142-90-9) → Norfloxacin hydrochloride (68077-27-0,104142-93-0)

Guidance literature:

7-{4-[(tert-butoxy)carbonyl]piperazin-1-yl}-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; With trifluoroacetic acid; In dichloromethane; at 20 ℃;

With hydrogenchloride; In water;

DOI:10.3762/bjoc.15.212

Reference yield: 95.0%

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid (70458-96-7) → Norfloxacin hydrochloride (68077-27-0,104142-93-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 1h;

Reference yield: 95.0%

C20H23BFN3O7 → Norfloxacin hydrochloride (68077-27-0,104142-93-0)

Guidance literature:

With hydrogenchloride; In water; at 0 ℃; for 4h; pH=< 1;

upstream raw materials:

piperazine

7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

1-ethyl-6-fluoro-7-chloro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester

ethyl 7-chloro-6-fluoro-4-oxo-1,4-dihydroquinoline 3-carboxylate

Downstream raw materials:

7-(4-(N-(3-chlorophenylsulfonyl)carbamimidoyl)piperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

1-ethyl-6-fluoro-4-oxo-7-(4-(N-(2-(trifluoromethyl)phenylsulfonyl)carbamimidoyl)piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid

7-(4-(N-(2-chlorophenylsulfonyl)carbamimidoyl)piperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

1-ethyl-6-fluoro-4-oxo-7-(4-(N-(4-(trifluoromethyl)phenylsulfonyl)carbamimidoyl)piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid

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