5-Pyridin-2-yl-2H-pyrazol-3-ylamine

Base Information

• Chemical Name: 5-Pyridin-2-yl-2H-pyrazol-3-ylamine
• CAS No.: 92352-29-9
• Molecular Formula: C8H8 N4
• Molecular Weight: 160.178
• Hs Code.: 2933990090
• European Community (EC) Number: 828-624-6
• DSSTox Substance ID: DTXSID10424394
• Nikkaji Number: J2.291.276C,J2.293.541K
• Wikidata: Q72504444
• ChEMBL ID: CHEMBL4130019
• Mol file: 92352-29-9.mol

Synonyms:92352-29-9;5-Pyridin-2-yl-2H-pyrazol-3-ylamine;3-(pyridin-2-yl)-1H-pyrazol-5-amine;5-pyridin-2-yl-1H-pyrazol-3-amine;1H-Pyrazol-3-amine, 5-(2-pyridinyl)-;MFCD06738755;5-(2-pyridinyl)-1H-pyrazol-3-amine;5-AMINO-3-(PYRID-2-YL)-1H-PYRAZOLE;5-(pyridin-2-yl)-1H-pyrazol-3-amine;SCHEMBL1593197;CHEMBL4130019;DTXSID10424394;RJFHMLHZCNZQMA-UHFFFAOYSA-N;HMS1699O06;3-(2-Pyridyl)-1H-pyrazole-5-amine;5-(2-Pyridyl)-1H-pyrazole-3-amine;AKOS005135729;AB27820;5-(pyridine-2-yl)-1H-pyrazol-3-amine;AS-62352;BP-21240;BB 0237301;CS-0070349;FT-0645256;EN300-235641;F31169;3-Pyridin-2-yl-1H-pyrazol-5-amine, AldrichCPR;A844206;F2381-0346;Z1021316366;(1R,2S)-METHYL1-AMINO-2-VINYLCYCLOPROPANECARBOXYLATEHCL

Chemical Property of 5-Pyridin-2-yl-2H-pyrazol-3-ylamine

Chemical Property:

• Vapor Pressure: 4.79E-09mmHg at 25°C
• Boiling Point: 471.1°C at 760 mmHg
• Flash Point: 270°C
• PSA: 67.59000
• Density: 1.315g/cm³
• LogP: 1.63510
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 160.074896272
• Heavy Atom Count: 12
• Complexity: 150

Purity/Quality:

97% ^*data from raw suppliers

5-Pyridin-2-yl-2H-pyrazol-3-ylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=NC(=C1)C2=CC(=NN2)N

Technology Process of 5-Pyridin-2-yl-2H-pyrazol-3-ylamine

There total 7 articles about 5-Pyridin-2-yl-2H-pyrazol-3-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

3-(pyridine-2-yl)-3-oxopropanenitrile (54123-21-6) → 3{5}-amino-5{3}-(pyrid-2-yl)-1H-pyrazole (92352-29-9)

Guidance literature:

With hydrazine; In ethanol; for 24h; Reflux;

Reference yield: 89.0%

3-(pyridine-2-yl)-3-oxopropanenitrile (54123-21-6) → 3{5}-amino-5{3}-(pyridin-2-yl)-1H-pyrazole (92352-29-9)

Guidance literature:

With hydrazine hydrate; In ethanol; for 20h; Heating;

DOI:10.1016/j.tetlet.2006.02.053

Reference yield: 88.0%

→ 3{5}-amino-5{3}-(pyrid-2-yl)-1H-pyrazole (92352-29-9)

Guidance literature:

With hydrazine hydrate; In ethanol; for 18h; Reflux;

upstream raw materials:

3-(pyridine-2-yl)-3-oxopropanenitrile

ethyl-2-picolinate

2-Picolinic acid

Downstream raw materials:

N¹,N³-bis(3-(pyridin-2-yl)-1H-pyrazole-5-yl)isophthalamide

C₂₆H₂₈N₁₀OS