(S)-2-{[2-(2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-4-decyl-phenyl]-methyl-amino}-3-methyl-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester

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Chemical Name:(S)-2-{[2-(2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-4-decyl-phenyl]-methyl-amino}-3-methyl-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester
CAS No.:1025820-59-0
Molecular Formula:C₃₄H₅₅N₃O₇
Molecular Weight:617.827
Hs Code.:

Synonyms:(S)-2-{[2-(2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-4-decyl-phenyl]-methyl-amino}-3-methyl-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester

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Chemical Property of (S)-2-{[2-(2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-4-decyl-phenyl]-methyl-amino}-3-methyl-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester

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Technology Process of (S)-2-{[2-(2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-4-decyl-phenyl]-methyl-amino}-3-methyl-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester

There total 15 articles about (S)-2-{[2-(2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-4-decyl-phenyl]-methyl-amino}-3-methyl-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64152-09-6
3-Methoxycarbonyl-4-nitrobenzoic acid

: 1025820-59-0
(S)-2-{[2-(2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-4-decyl-phenyl]-methyl-amino}-3-methyl-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester

Guidance literature:: Multi-step reaction with 16 steps

1: 91 percent / BH₃*methyl sulfide / tetrahydrofuran / 5 h / Heating

2: 94 percent / PCC, neutral activity I Al₂O₃ / CH₂Cl₂ / 18 h / 0 °C

3: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 40 min, 2.) THF, hexane, 0 deg C, 3.5 h

4: 82 percent / LiBH₄ / tetrahydrofuran / 17 h / 0 - 20 °C

5: NaH / toluene / 2 h / Ambient temperature

6: 77 percent / NaH / dimethylformamide / 16 h / Ambient temperature

7: conc. aq. HCl / acetic acid / 24 h / Heating

8: SOCl₂ / 30 h / Ambient temperature

9: CH₂Cl₂ / 18 h / Ambient temperature

10: 49 percent / LiBH₄ / tetrahydrofuran / 18.5 h / 0 - 20 °C

11: 92 percent / H₂ / 10percent Pd/C / ethanol / 10 h / Ambient temperature

12: 93 percent / acetic anhydride / tetrahydrofuran / 4 h / 20 - 70 °C

13: 99 percent / BH₃ / tetrahydrofuran / 2.5 h / 0 °C

14: 86 percent / 2,6-lutidine / 1,2-dichloro-ethane / 24 h / Heating

15: H₂ / 10percent Pd/C / ethanol / 2 h / 760 Torr / Ambient temperature

16: DCC / acetonitrile / 2 h / Ambient temperature

With 2,6-dimethylpyridine; hydrogenchloride; aluminum oxide; lithium borohydride; n-butyllithium; thionyl chloride; dimethylsulfide borane complex; borane; hydrogen; acetic anhydride; sodium hydride; dicyclohexyl-carbodiimide; pyridinium chlorochromate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; acetic acid; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jm970704s

Reference yield:

: 168965-88-6
[2-(5-Decyl-2-methylamino-phenyl)-1-hydroxymethyl-ethyl]-carbamic acid tert-butyl ester

: 1025820-59-0
(S)-2-{[2-(2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-4-decyl-phenyl]-methyl-amino}-3-methyl-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / 2,6-lutidine / 1,2-dichloro-ethane / 24 h / Heating

2: H₂ / 10percent Pd/C / ethanol / 2 h / 760 Torr / Ambient temperature

3: DCC / acetonitrile / 2 h / Ambient temperature

With 2,6-dimethylpyridine; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethanol; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1021/jm970704s

Reference yield:

: 133719-03-6
5-hydroxymethyl-2-nitro-benzoic acid methyl ester

: 1025820-59-0
(S)-2-{[2-(2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-4-decyl-phenyl]-methyl-amino}-3-methyl-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester

Guidance literature:: Multi-step reaction with 15 steps

1: 94 percent / PCC, neutral activity I Al₂O₃ / CH₂Cl₂ / 18 h / 0 °C

2: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 40 min, 2.) THF, hexane, 0 deg C, 3.5 h

3: 82 percent / LiBH₄ / tetrahydrofuran / 17 h / 0 - 20 °C

4: NaH / toluene / 2 h / Ambient temperature

5: 77 percent / NaH / dimethylformamide / 16 h / Ambient temperature

6: conc. aq. HCl / acetic acid / 24 h / Heating

7: SOCl₂ / 30 h / Ambient temperature

8: CH₂Cl₂ / 18 h / Ambient temperature

9: 49 percent / LiBH₄ / tetrahydrofuran / 18.5 h / 0 - 20 °C

10: 92 percent / H₂ / 10percent Pd/C / ethanol / 10 h / Ambient temperature

11: 93 percent / acetic anhydride / tetrahydrofuran / 4 h / 20 - 70 °C

12: 99 percent / BH₃ / tetrahydrofuran / 2.5 h / 0 °C

13: 86 percent / 2,6-lutidine / 1,2-dichloro-ethane / 24 h / Heating

14: H₂ / 10percent Pd/C / ethanol / 2 h / 760 Torr / Ambient temperature

15: DCC / acetonitrile / 2 h / Ambient temperature

With 2,6-dimethylpyridine; hydrogenchloride; aluminum oxide; lithium borohydride; n-butyllithium; thionyl chloride; borane; hydrogen; acetic anhydride; sodium hydride; dicyclohexyl-carbodiimide; pyridinium chlorochromate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; acetic acid; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jm970704s