3,5-difluoro-4-[(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]aniline

Base Information

Chemical Name:3,5-difluoro-4-[(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]aniline
CAS No.:1115491-41-2
Molecular Formula:C₁₉H₂₃F₂N₃O₂Si
Molecular Weight:391.493
Hs Code.:

Synonyms:3,5-difluoro-4-[(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]aniline

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Chemical Property of 3,5-difluoro-4-[(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]aniline

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Technology Process of 3,5-difluoro-4-[(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]aniline

There total 6 articles about 3,5-difluoro-4-[(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1115491-38-7
C₁₉H₂₂ClF₂N₃O₂Si

: 1115491-41-2
3,5-difluoro-4-[(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]aniline

Guidance literature:: With 1% Pd/C; hydrogen; triethylamine; In ethanol; at 20 ℃;
DOI:10.1021/op900260k

Reference yield:

: 4-(2,6-difluoro-4-nitrophenoxy)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridine

: 1115491-41-2
3,5-difluoro-4-[(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]aniline

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 20 ℃; for 2h;

Reference yield:

: 66684-58-0
3,4,5-trifluoronitrobenzene

: 1115491-41-2
3,5-difluoro-4-[(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]aniline

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / dimethyl sulfoxide / 1 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C / Cooling with ice

3: hydrogen; palladium 10% on activated carbon / ethyl acetate / 2 h / 20 °C

With palladium 10% on activated carbon; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; ethyl acetate; acetonitrile;