CarbaMic acid, (2-chloro-3-iodo-4-pyridinyl)-, 1,1-diMethylethyl ester (9CI)

Base Information

• Chemical Name: CarbaMic acid, (2-chloro-3-iodo-4-pyridinyl)-, 1,1-diMethylethyl ester (9CI)
• CAS No.: 234108-74-8
• Molecular Formula: C₁₀H₁₂ClIN₂O₂
• Molecular Weight: 354.575
• Mol file: 234108-74-8.mol

Synonyms:(2-chloro-3-iodo-pyridin-4-yl)-carbamic acid tert-butyl ester;TERT-BUTYL (2-CHLORO-3-IODOPYRIDIN-4-YL)CARBAMATE;Carbamic acid,(2-chloro-3-iodo-4-pyridinyl)-,1,1-dimethylethyl ester;

Chemical Property of CarbaMic acid, (2-chloro-3-iodo-4-pyridinyl)-, 1,1-diMethylethyl ester (9CI)

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 341.805oC at 760 mmHg
• PKA: 11.18±0.70(Predicted)
• Flash Point: 160.518oC
• PSA: 54.71000
• Density: 1.724g/cm3
• LogP: 3.70020
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

(2-CHLORO-3-IODOPYRIDIN-4-YL) CARBAMIC ACID tert-BUTYL ESTER 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CarbaMic acid, (2-chloro-3-iodo-4-pyridinyl)-, 1,1-diMethylethyl ester (9CI)

There total 4 articles about CarbaMic acid, (2-chloro-3-iodo-4-pyridinyl)-, 1,1-diMethylethyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

2-chloro-3-iodo-pyridin-4-ylamine (909036-46-0) + di-tert-butyl dicarbonate (24424-99-5) → (2-chloro-3-iodo-pyridin-4-yl)-carbamic acid tert-butyl ester (234108-74-8)

Guidance literature:

In tetrahydrofuran; for 1h; Cooling with ice;

Reference yield: 56.0%

2-chloro-3-iodo-pyridin-4-ylamine (909036-46-0) + tert-butyldicarbonate (34619-03-9) → (2-chloro-3-iodo-pyridin-4-yl)-carbamic acid tert-butyl ester (234108-74-8)

Guidance literature:

In tetrahydrofuran; for 1h; Cooling with ether-dry ice;

Reference yield: 55.0%

(2-chloro-pyridin-4-yl)-carbamic acid tert-butyl ester (234108-73-7) → (2-chloro-3-iodo-pyridin-4-yl)-carbamic acid tert-butyl ester (234108-74-8)

Guidance literature:

(2-chloro-pyridin-4-yl)-carbamic acid tert-butyl ester; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; hexanes; at -78 ℃; for 4.25h;

With iodine; In tetrahydrofuran; hexanes; at -78 ℃; for 2.25h;

upstream raw materials:

(2-chloro-pyridin-4-yl)-carbamic acid tert-butyl ester

4-Amino-2-chloropyridine

2-chloro-3-iodo-pyridin-4-ylamine

di-tert-butyl dicarbonate

Downstream raw materials:

4-chloro-2-methyl-1H-pyrrolo[3,2-c]pyridine

{2-Methyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetic acid

Ethyl {2-methyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetate

Ethyl {2,5-dimethyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetate