[(1S,2S)-2,3-Bis-(tert-butyl-dimethyl-silanyloxy)-1-phenethyl-propyl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:[(1S,2S)-2,3-Bis-(tert-butyl-dimethyl-silanyloxy)-1-phenethyl-propyl]-carbamic acid tert-butyl ester
CAS No.:197231-58-6
Molecular Formula:C₂₈H₅₃NO₄Si₂
Molecular Weight:523.904
Hs Code.:

Synonyms:[(1S,2S)-2,3-Bis-(tert-butyl-dimethyl-silanyloxy)-1-phenethyl-propyl]-carbamic acid tert-butyl ester

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Chemical Property of [(1S,2S)-2,3-Bis-(tert-butyl-dimethyl-silanyloxy)-1-phenethyl-propyl]-carbamic acid tert-butyl ester

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Technology Process of [(1S,2S)-2,3-Bis-(tert-butyl-dimethyl-silanyloxy)-1-phenethyl-propyl]-carbamic acid tert-butyl ester

There total 5 articles about [(1S,2S)-2,3-Bis-(tert-butyl-dimethyl-silanyloxy)-1-phenethyl-propyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 154079-57-9
(2S,3S)-3-(tert-butoxycarbonylamino)-5-phenyl-1,2-pentanediol

: 197231-58-6
[(1S,2S)-2,3-Bis-(tert-butyl-dimethyl-silanyloxy)-1-phenethyl-propyl]-carbamic acid tert-butyl ester

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 35 ℃; for 16h;
DOI:10.1016/S0957-4166(97)00346-7

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 197231-58-6
[(1S,2S)-2,3-Bis-(tert-butyl-dimethyl-silanyloxy)-1-phenethyl-propyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / H₂ / 10percent Pd(OH)2/C / ethyl acetate / Ambient temperature

2: 96 percent / imidazole / dimethylformamide / 16 h / 35 °C

With 1H-imidazole; hydrogen; palladium dihydroxide; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0957-4166(97)00346-7

Reference yield:

: 75553-23-0
(E)-5-phenyl-2-penten-1-ol

: 197231-58-6
[(1S,2S)-2,3-Bis-(tert-butyl-dimethyl-silanyloxy)-1-phenethyl-propyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) D-(-)-diisopropyl tartrate, Ti(OiPr)4, 4 Angstroem molecular sieves, 2.) tert-butyl hydroperoxide / 1.) CH₂Cl₂, -30 deg C, 1 h, 2.) CH₂Cl₂, isooctane, -30 deg C, 25 h

2: 87 percent / Ti(OiPr)4 / CH₂Cl₂ / 72 h / Heating

3: 93 percent / H₂ / 10percent Pd(OH)2/C / ethyl acetate / Ambient temperature

4: 96 percent / imidazole / dimethylformamide / 16 h / 35 °C

With 1H-imidazole; titanium(IV) isopropylate; tert.-butylhydroperoxide; 4 A molecular sieve; hydrogen; D-(-)-diisopropyl tartrate; palladium dihydroxide; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0957-4166(97)00346-7