Technology Process of 3-benzyloxy-2-(2-methoxyethoxy)-estra-1,3,5(10)-triene-17β-ol
There total 5 articles about 3-benzyloxy-2-(2-methoxyethoxy)-estra-1,3,5(10)-triene-17β-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
di-isopropyl azodicarboxylate; triphenylphosphine;
In
dichloromethane;
at 0 - 20 ℃;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: pyridine / 20 °C
2.1: zirconium(IV) chloride / dichloromethane / 48 h / 20 °C
2.2: 0 - 20 °C
3.1: potassium carbonate / 18-crown-6 ether / acetone / 108 h / 56 °C
4.1: sodium dihydrogenphosphate; 3-chloro-benzenecarboperoxoic acid / dichloromethane; water / 20 °C
5.1: methanol; potassium hydroxide; water / tetrahydrofuran / 65 °C
6.1: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 0 - 20 °C
With
pyridine; methanol; potassium hydroxide; sodium dihydrogenphosphate; di-isopropyl azodicarboxylate; water; zirconium(IV) chloride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine;
18-crown-6 ether;
In
tetrahydrofuran; dichloromethane; water; acetone;
2.1: Fries Rearrangement / 4.1: Baeyer-Villiger Oxidation / 6.1: Mitsunobu reaction;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: potassium carbonate / 18-crown-6 ether / acetone / 108 h / 56 °C
2: sodium dihydrogenphosphate; 3-chloro-benzenecarboperoxoic acid / dichloromethane; water / 20 °C
3: methanol; potassium hydroxide; water / tetrahydrofuran / 65 °C
4: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 0 - 20 °C
With
methanol; potassium hydroxide; sodium dihydrogenphosphate; di-isopropyl azodicarboxylate; water; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine;
18-crown-6 ether;
In
tetrahydrofuran; dichloromethane; water; acetone;
2: Baeyer-Villiger Oxidation / 4: Mitsunobu reaction;
