4-bromo-3,5-bis-(4-methoxybenzyloxy)-benzoic acid methyl ester

Base Information

• Chemical Name: 4-bromo-3,5-bis-(4-methoxybenzyloxy)-benzoic acid methyl ester
• CAS No.: 444119-54-4
• Molecular Formula: C₂₄H₂₃BrO₆
• Molecular Weight: 487.347
• Mol file: 444119-54-4.mol

Synonyms:4-bromo-3,5-bis-(4-methoxybenzyloxy)-benzoic acid methyl ester

Chemical Property of 4-bromo-3,5-bis-(4-methoxybenzyloxy)-benzoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 4-bromo-3,5-bis-(4-methoxybenzyloxy)-benzoic acid methyl ester

There total 2 articles about 4-bromo-3,5-bis-(4-methoxybenzyloxy)-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

4-bromo-3,5-dihydroxy-benzoic acid methyl ester (34126-16-4) + p-methoxybenzyl chloride (824-94-2) → 4-bromo-3,5-bis-(4-methoxybenzyloxy)-benzoic acid methyl ester (444119-54-4)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 12h;

DOI:10.1002/1521-3765(20020415)8:8<1850::AID-CHEM1850>3.0.CO;2-Q

Reference yield:

3,5-dihydroxy-4-bromobenzoic acid (16534-12-6) → 4-bromo-3,5-bis-(4-methoxybenzyloxy)-benzoic acid methyl ester (444119-54-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / SOCl₂ / 2 h / Heating

2: 84 percent / K₂CO₃; nBu₄NI / dimethylformamide / 12 h / 80 °C

With thionyl chloride; tetra-(n-butyl)ammonium iodide; potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1002/1521-3765(20020415)8:8<1850::AID-CHEM1850>3.0.CO;2-Q

Reference yield: 98.0%

4-bromo-3,5-bis-(4-methoxybenzyloxy)-benzoic acid methyl ester (444119-54-4) → [4-bromo-3,5-bis-(4-methoxybenzyloxy)-phenyl]-methanol (444119-55-5)

Guidance literature:

With lithium borohydride; In tetrahydrofuran; methanol; for 3h; Heating;

DOI:10.1002/1521-3765(20020415)8:8<1850::AID-CHEM1850>3.0.CO;2-Q

upstream raw materials:

4-bromo-3,5-dihydroxy-benzoic acid methyl ester

p-methoxybenzyl chloride

3,5-dihydroxy-4-bromobenzoic acid

Downstream raw materials:

[4-bromo-3,5-bis-(4-methoxybenzyloxy)-phenyl]-methanol

[4-bromo-3,5-bis-(4-methoxybenzyloxy)-benzyloxy]-tert-butyldiphenylsilane

4'-bromomethyl-2-methoxy-4,2',6'-tris-(4-methoxybenzyloxy)-6-pent-4-enyl-biphenyl

[2'-methoxy-2,6,4'-tris-(4-methoxybenzyloxy)-6'-pent-4-enyl-biphenyl-4-yl]-methanol