34126-16-4

Usage

Uses

Used in Pharmaceutical Synthesis:
Methyl 4-bromo-3,5-dihydroxy-benzoate is used as an intermediate in the synthesis of pharmaceuticals for its versatile chemical structure that can be further modified to create various medicinal compounds.
Used in Agrochemical Production:
In the agrochemical industry, methyl 4-bromo-3,5-dihydroxy-benzoate is utilized as a building block in the development of new agrochemicals, potentially contributing to pest control and crop protection.
Used in Organic Chemistry Research:
As a reagent in organic chemistry, methyl 4-bromo-3,5-dihydroxy-benzoate is employed in various research applications to explore its chemical properties and reactions, aiding in the advancement of organic synthesis techniques.
Used in Biological Activity Studies:
Methyl 4-bromo-3,5-dihydroxy-benzoate is used in biological research as a compound with potential anti-inflammatory and antioxidant properties, which can be further investigated for therapeutic applications in medicine.
Used in Commercial Applications:
methyl 4-bromo-3,5-dihydroxy-benzoate is also used in commercial applications, being available for purchase by researchers and industries for a variety of purposes, including the development of new products and technologies that leverage its chemical properties.

InChI:InChI=1/C8H7BrO4/c1-13-8(12)4-2-5(10)7(9)6(11)3-4/h2-3,10-11H,1H3

Upstream product

• 67-56-1 methanol 
• 16534-12-6 3,5-dihydroxy-4-bromobenzoic acid 
• 75-77-4 chloro-trimethyl-silane 
• 99-10-5 3,5-Dihydroxybenzoic acid 

Downstream Products

• 331943-76-1 [4-bromo-3,5-bis-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-methanol 
• 331943-78-3 2-bromo-5-methoxymethyl-1,3-bis[(2-trimethylsilylethoxy)methoxy]-benzene 
• 149517-94-2 methyl 4-bromo-5-ethoxy-3-hydroxybenzoate 
• 26050-64-6 methyl 4-bromo-3,5-dimethoxybenzoate 

Relevant academic research and scientific papers

Impact of substitution pattern and chain length on the thermotropic properties of alkoxy-substituted triphenyl-tristriazolotriazines

Tristriazolotriazines (TTTs) with a threefold alkoxyphenyl substitution were prepared and studied by DSC, polarized optical microscopy (POM) and X-ray scattering. Six pentyloxy chains are sufficient to induce liquid-crystalline behavior in these star-shap

Btk INHIBITORS WITH IMPROVED DUAL SELECTIVITY

Disclosed herein is a tri-substituted phenyl Btk inhibitors with improved dual selectivity, a method and a composition for inhibiting Btk and treating disease associated with undesirable Btk activity (Btk-related diseases).

Total Synthesis of Gramistilbenoids A, B, and C

Stilbenes are biologically active metabolites of plants that have the potential to attenuate a broad range of human diseases. Gramistilbenoids are a class of natural products with a stilbene skeleton, isolated from the bamboo orchid (Arundina graminifolia), and with significant cytotoxicity against cancer cell lines (NB4, A549, SHSY5Y, PC3, and MCF7). These are the first identified naturally occurring diphenylethylenes to possess a hydroxyethyl unit. However, some of these compounds are not abundant in nature, and thus, their synthesis is advantageous. This paper reports the first synthesis of gramistilbenoids A (1), B (2), and C (3), with overall yields of 10, 2, and 8% respectively. These natural products were synthesized using key reactions, such as Horner-Wadsworth-Emmons olefination, Stille coupling, and hydroboration-oxidation.

Synthesis and NMR analysis of a conformationally controlled β-Turn Mimetic Torsion Balance

The molecular torsion balance concept was applied to a new conformationally controlled scaffold and synthesized to accurately evaluate pairwise amino acid interactions in an antiparallel β-sheet motif. The scaffold's core design combines (ortho-tolyl)amide and o,o,o′-trisubstituted biphenyl structural units to provide a geometry better-suited for intramolecular hydrogen bonding. Like the dibenzodiazocine hinge of the traditional torsion balance, the (ortho-tolyl)amide unit offers restricted rotation around an N-aryl bond. The resulting two-state folding model is a powerful template for measuring hydrogen bond stability between two competing sequences. The aim of this study was to improve the alignment between the amino acid sequences attached to the upper and lower aromatic rings in order to promote hydrogen bond formation at the correct distance and antiparallel orientation. Bromine substituents were introduced ortho to the upper side chains and compared to a control to test our hypothesis. Hydrogen bond formation has been identified between the NH amide proton of the upper side chain (proton donor) and glycine acetamide of the lower side chain (proton acceptor).

Heterocyclic compound and application thereof

The invention belongs to the field of medical chemistry, and relates to a heterocyclic compound and application thereof. Concretely, the invention provides a compound as shown in a formula I, or an isomer, pharmaceutically acceptable salts, and a solvate

Ruthenium-Catalyzed Hydroarylation and One-Pot Twofold Unsymmetrical C?H Functionalization of Arenes

A methyl phenyl sulfoximine (MPS) is used as a directing group in the ruthenium-catalyzed intramolecular hydroarylation of alkene-tethered benzoic acid derivatives to afford dihydrobenzofurans and indolines in good to excellent yields. A one-pot, unsymmetrical, twofold C?H functionalization involving intramolecular C?C and intermolecular C?C/C?N bond formations is successfully demonstrated by using a single set of catalytic reaction conditions, which is unprecedented thus far. A novel isoquinolone-bearing dihydrobenzofuran is constructed through an unsymmetrical twofold C?H functionalization.

LIPIDS AND LIPID COMPOSITIONS FOR THE DELIVERY OF ACTIVE AGENTS

This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1–R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.

New meso-substituted trans-A2B2 di(4-pyridyl) porphyrins as building blocks for metal-mediated self-assembling of 4 + 4 Re(i)-porphyrin metallacycles

The reaction between 5-(4-pyridyl)dipyrrylmethane and aromatic aldehydes affords meso-arylsubstituted trans-A2B2 di(4-pyridyl)porphyrins which are key building blocks in the metal-mediated self-assembling of supramolecular structures

SPIROCHROMANON DERIVATIVES

The invention relates to a compound of a general formula (I): wherein Ar1 represents a group formed from an aromatic ring selected from a group consisting of benzene, pyrazole, isoxazole, pyridine, indole, 1H-indazole, 1H-furo[2,3-c]pyrazole, 1H-thieno[2,3-c]pyrazole, benzimidazole, 1,2-benzisoxazole, imidazo[1,2-a]pyridine, imidazo[1,5-a]pyridine and 1H-pyrazolo[3,4-b]pyridine, having Ar2, and optionally having one or two or more substituents selected from R3; R1 and R2 each independently represent a hydrogen atom, a halogen atom, a cyano group, a C2-C6 alkenyl group, a C1-C6 alkoxy group, a C2-C7 alkanoyl group, a C2-C7 alkoxycarbonyl group, an aralkyloxycarbonyl group, a carbamoyl-C1-C6 alkoxy group, a carboxy-C2-C6 alkenyl group, or a group of -Q1-N(Ra)-Q2-Rb; or a C1-C6 alkyl group optionally having a substituent; or an aryl or heterocyclic group optionally having a substituent; or a C1-C6 alkyl group or a C2-C6 alkenyl group having the aryl or heterocyclic group; T and U each independently represent a nitrogen atom or a methine group; and V represents an oxygen atom or a sulfur atom. The compound of the invention is useful as therapeutical agents for various ACC-related diseases.

A new family of biisoquinoline chelates

Four 8,8′-diaryl-substituted 3,3′-biisoquinoline ligands have been synthesized and characterized. The key feature of this new family of chelates is their endotopic but sterically non-hindering nature. All four ligands were made from a common 8-bromoisoquinolin-3-ol precursor; between three and twelve synthetic steps were necessary to obtain the products. The reported synthetic procedures allow for gram-scale production of these biisoquinolines. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.