(2S,4S)-tert-butyl 2-(6-(4'-(2-((2S,4S)-1-(tert-butoxycarbonyl)-4-methylpyrrolidin-2-yl)-1H-imidazol-4-yl)-[1,1'-biphenyl]-4-yl)-3H-benzo[d]imidazol-2-yl)-4-methylpyrrolidine-1-carboxylate

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Chemical Name:(2S,4S)-tert-butyl 2-(6-(4'-(2-((2S,4S)-1-(tert-butoxycarbonyl)-4-methylpyrrolidin-2-yl)-1H-imidazol-4-yl)-[1,1'-biphenyl]-4-yl)-3H-benzo[d]imidazol-2-yl)-4-methylpyrrolidine-1-carboxylate
CAS No.:1335316-14-7
Molecular Formula:C₄₂H₅₀N₆O₄
Molecular Weight:702.897
Hs Code.:

(2S,4S)-tert-butyl 2-(6-(4'-(2-((2S,4S)-1-(tert-butoxycarbonyl)-4-methylpyrrolidin-2-yl)-1H-imidazol-4-yl)-[1,1'-biphenyl]-4-yl)-3H-benzo[d]imidazol-2-yl)-4-methylpyrrolidine-1-carboxylate

Synonyms:(2S,4S)-tert-butyl 2-(6-(4'-(2-((2S,4S)-1-(tert-butoxycarbonyl)-4-methylpyrrolidin-2-yl)-1H-imidazol-4-yl)-[1,1'-biphenyl]-4-yl)-3H-benzo[d]imidazol-2-yl)-4-methylpyrrolidine-1-carboxylate

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Chemical Property of (2S,4S)-tert-butyl 2-(6-(4'-(2-((2S,4S)-1-(tert-butoxycarbonyl)-4-methylpyrrolidin-2-yl)-1H-imidazol-4-yl)-[1,1'-biphenyl]-4-yl)-3H-benzo[d]imidazol-2-yl)-4-methylpyrrolidine-1-carboxylate

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Technology Process of (2S,4S)-tert-butyl 2-(6-(4'-(2-((2S,4S)-1-(tert-butoxycarbonyl)-4-methylpyrrolidin-2-yl)-1H-imidazol-4-yl)-[1,1'-biphenyl]-4-yl)-3H-benzo[d]imidazol-2-yl)-4-methylpyrrolidine-1-carboxylate

There total 4 articles about (2S,4S)-tert-butyl 2-(6-(4'-(2-((2S,4S)-1-(tert-butoxycarbonyl)-4-methylpyrrolidin-2-yl)-1H-imidazol-4-yl)-[1,1'-biphenyl]-4-yl)-3H-benzo[d]imidazol-2-yl)-4-methylpyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1335137-75-1
(2S,4S)-4-methyl-2-{4-[4'-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-biphenyl-4-yl]-1H-imidazol-2-yl}-pyrrolidine-1-carboxylic acid tert-butyl ester

: 1335208-93-9
tert-butyl (2S,4S)-2-(5-iodo-1H-benzimidazol-2-yl)-4-methyl-pyrrolidine-1-carboxylate

: 1335316-14-7
(2S,4S)-tert-butyl 2-(6-(4'-(2-((2S,4S)-1-(tert-butoxycarbonyl)-4-methylpyrrolidin-2-yl)-1H-imidazol-4-yl)-[1,1'-biphenyl]-4-yl)-3H-benzo[d]imidazol-2-yl)-4-methylpyrrolidine-1-carboxylate

Guidance literature:: With sodium 2'‐(dicyclohexylphosphaneyl)‐2,6‐diisopropyl‐[1,1'‐biphenyl]‐3‐sulfonate; sodium hydrogencarbonate; palladium diacetate; In water; isopropyl alcohol; at 100 ℃; for 8h; Inert atmosphere;

Reference yield:

: 84348-38-9,1427175-11-8
(S)-1-(tert-butoxycarbonyl)-4-methylenepyrrolidine-2-carboxylic acid

: 1335316-14-7
(2S,4S)-tert-butyl 2-(6-(4'-(2-((2S,4S)-1-(tert-butoxycarbonyl)-4-methylpyrrolidin-2-yl)-1H-imidazol-4-yl)-[1,1'-biphenyl]-4-yl)-3H-benzo[d]imidazol-2-yl)-4-methylpyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / platinum(IV) oxide / methanol / 20 h / 760.05 Torr / Inert atmosphere

2.1: 2,4,6-trimethyl-pyridine; HATU / N,N-dimethyl-formamide / 20 °C

2.2: 50 °C

3.1: sodium hydrogencarbonate; sodium 2'‐(dicyclohexylphosphaneyl)‐2,6‐diisopropyl‐[1,1'‐biphenyl]‐3‐sulfonate / palladium diacetate / isopropyl alcohol; water / 8 h / 100 °C / Inert atmosphere

With sodium 2'‐(dicyclohexylphosphaneyl)‐2,6‐diisopropyl‐[1,1'‐biphenyl]‐3‐sulfonate; 2,4,6-trimethyl-pyridine; hydrogen; sodium hydrogencarbonate; HATU; platinum(IV) oxide; palladium diacetate; In methanol; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 871727-77-4
N-Boc-4-methyl-L-proline

: 1335316-14-7
(2S,4S)-tert-butyl 2-(6-(4'-(2-((2S,4S)-1-(tert-butoxycarbonyl)-4-methylpyrrolidin-2-yl)-1H-imidazol-4-yl)-[1,1'-biphenyl]-4-yl)-3H-benzo[d]imidazol-2-yl)-4-methylpyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2,4,6-trimethyl-pyridine; HATU / N,N-dimethyl-formamide / 20 °C

1.2: 50 °C

2.1: sodium hydrogencarbonate; sodium 2'‐(dicyclohexylphosphaneyl)‐2,6‐diisopropyl‐[1,1'‐biphenyl]‐3‐sulfonate / palladium diacetate / isopropyl alcohol; water / 8 h / 100 °C / Inert atmosphere

With sodium 2'‐(dicyclohexylphosphaneyl)‐2,6‐diisopropyl‐[1,1'‐biphenyl]‐3‐sulfonate; 2,4,6-trimethyl-pyridine; sodium hydrogencarbonate; HATU; palladium diacetate; In water; N,N-dimethyl-formamide; isopropyl alcohol;