8-cyclohexyl-N-((dimethylamino)sulfonyl)-11-methoxy-1a-((3-(1-piperidinyl)-8-azabicyclo[3.2.1]oct-8-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide

Base Information

Chemical Name:8-cyclohexyl-N-((dimethylamino)sulfonyl)-11-methoxy-1a-((3-(1-piperidinyl)-8-azabicyclo[3.2.1]oct-8-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide
CAS No.:1058165-55-1
Molecular Formula:C₄₁H₅₃N₅O₅S
Molecular Weight:727.968
Hs Code.:

8-cyclohexyl-N-((dimethylamino)sulfonyl)-11-methoxy-1a-((3-(1-piperidinyl)-8-azabicyclo[3.2.1]oct-8-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide

Synonyms:8-cyclohexyl-N-((dimethylamino)sulfonyl)-11-methoxy-1a-((3-(1-piperidinyl)-8-azabicyclo[3.2.1]oct-8-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide

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Chemical Property of 8-cyclohexyl-N-((dimethylamino)sulfonyl)-11-methoxy-1a-((3-(1-piperidinyl)-8-azabicyclo[3.2.1]oct-8-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide

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Technology Process of 8-cyclohexyl-N-((dimethylamino)sulfonyl)-11-methoxy-1a-((3-(1-piperidinyl)-8-azabicyclo[3.2.1]oct-8-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide

There total 8 articles about 8-cyclohexyl-N-((dimethylamino)sulfonyl)-11-methoxy-1a-((3-(1-piperidinyl)-8-azabicyclo[3.2.1]oct-8-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 959983-22-3
cycloprop[d]indolo[2,1-a][2]benzazepine-1a(2H)-carboxylic acid, 8-cyclohexyl-5-[[[(dimethylamino)sulfonyl]amino]carbonyl]-1,12b-dihydro-11-methoxy-, (+/-)-

: 923944-33-6
3-(piperidin-1-yl)-8-azabicyclo[3.2.1]octane

: 1058165-55-1
8-cyclohexyl-N-((dimethylamino)sulfonyl)-11-methoxy-1a-((3-(1-piperidinyl)-8-azabicyclo[3.2.1]oct-8-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide

Guidance literature:: With triethylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 902148-54-3
13-cyclohexyl-10-[[[(dimethylamino)sulfonyl]amino]carbonyl]-3-methoxy-7H-indolo[2,1-a][2]benzazepine-6-carboxylic acid methyl ester

: 1058165-55-1
8-cyclohexyl-N-((dimethylamino)sulfonyl)-11-methoxy-1a-((3-(1-piperidinyl)-8-azabicyclo[3.2.1]oct-8-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 30 °C

1.2: 0.5 h / 30 °C

2.1: sodium hydroxide; water / tetrahydrofuran; methanol / 0.08 h / 90 °C / Microwave irradiation

3.1: triethylamine; HATU / N,N-dimethyl-formamide / 20 °C

With sodium hydroxide; water; sodium hydride; triethylamine; HATU; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 494799-76-7
2-bromo-3-cyclohexyl-1H-indole-6-carboxylic acid

: 1058165-55-1
8-cyclohexyl-N-((dimethylamino)sulfonyl)-11-methoxy-1a-((3-(1-piperidinyl)-8-azabicyclo[3.2.1]oct-8-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 - 2 h / 22 - 50 °C

1.2: 21 - 24 h / 20 - 30 °C

2.1: lithium chloride / ethanol; toluene / 0.25 h

2.2: 0.17 h

2.3: 20 h / 70 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 55 - 60 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 30 °C

4.2: 0.5 h / 30 °C

5.1: sodium hydroxide; water / tetrahydrofuran; methanol / 0.08 h / 90 °C / Microwave irradiation

6.1: triethylamine; HATU / N,N-dimethyl-formamide / 20 °C

With sodium hydroxide; water; sodium hydride; caesium carbonate; triethylamine; HATU; 1,1'-carbonyldiimidazole; lithium chloride; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; toluene;