Technology Process of 2-broMo-3-cyclohexyl-1H-indole-6-carboxylic acid
There total 6 articles about 2-broMo-3-cyclohexyl-1H-indole-6-carboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
methyl 2-bromo-3-cyclohexyl-1H-indole-6-carboxylate;
With
methanol; lithium hydroxide; water;
In
tetrahydrofuran;
at 90 ℃;
for 2h;
With
hydrogenchloride;
In
tetrahydrofuran; methanol; water;
at 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triethylsilane; trifluoroacetic acid / dichloromethane / 12 h / 10 - 20 °C
2.1: pyridinium hydrobromide perbromide / tetrahydrofuran; chloroform / 2 - 2.66 h / 0 - 20 °C
3.1: methanol; lithium hydroxide; water / tetrahydrofuran / 2 - 3 h / 90 °C
3.2: 1 h / 0 - 20 °C
With
methanol; triethylsilane; lithium hydroxide; water; pyridinium hydrobromide perbromide; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; chloroform;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 18 h / 20 °C / 2844.39 Torr
2.1: thionyl chloride / 18 h / Heating / reflux
3.1: pyridinium hydrobromide perbromide / tetrahydrofuran; chloroform / 2 - 2.66 h / 0 - 20 °C
4.1: methanol; lithium hydroxide; water / tetrahydrofuran / 2 - 3 h / 90 °C
4.2: 1 h / 0 - 20 °C
With
methanol; lithium hydroxide; thionyl chloride; water; hydrogen; pyridinium hydrobromide perbromide;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; chloroform;