4-[4-(ethoxycarbonylphenylhydrazono)methyl-3-4-fluorophenyl]sydnone

Base Information

• Chemical Name: 4-[4-(ethoxycarbonylphenylhydrazono)methyl-3-4-fluorophenyl]sydnone
• CAS No.: 895632-92-5
• Molecular Formula: C₁₈H₁₅FN₄O₄
• Molecular Weight: 370.34
• Mol file: 895632-92-5.mol

Synonyms:4-[4-(ethoxycarbonylphenylhydrazono)methyl-3-4-fluorophenyl]sydnone

Chemical Property of 4-[4-(ethoxycarbonylphenylhydrazono)methyl-3-4-fluorophenyl]sydnone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[4-(ethoxycarbonylphenylhydrazono)methyl-3-4-fluorophenyl]sydnone

There total 2 articles about 4-[4-(ethoxycarbonylphenylhydrazono)methyl-3-4-fluorophenyl]sydnone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

C9H5FN2O3 (895632-89-0) + 4-ethoxycarbonylphenylhydrazine hydrochloride (40566-85-6) → 4-[4-(ethoxycarbonylphenylhydrazono)methyl-3-4-fluorophenyl]sydnone (895632-92-5)

Guidance literature:

In ethanol; at 20 ℃; for 3h;

DOI:10.1246/bcsj.79.644

Reference yield:

3-(4-fluorophenyl)-3H-1,2,3-oxadiazol-1-ium-5-olate (5352-95-4) → 4-[4-(ethoxycarbonylphenylhydrazono)methyl-3-4-fluorophenyl]sydnone (895632-92-5)

Guidance literature:

Multi-step reaction with 2 steps

1: POCl₃

2: 81 percent / ethanol / 3 h / 20 °C

With trichlorophosphate; In ethanol; 1: Schmidt reaction;

DOI:10.1246/bcsj.79.644

Reference yield: 52.0%

4-[4-(ethoxycarbonylphenylhydrazono)methyl-3-4-fluorophenyl]sydnone (895632-92-5) → ethyl 4-[4-(4-fluorophenylamino)-2H-1,2,3-triazol-2-yl]benzoate (895632-96-9)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 60 ℃;

DOI:10.1246/bcsj.79.644

upstream raw materials:

C₉H₅FN₂O₃

4-ethoxycarbonylphenylhydrazine hydrochloride

3-(4-fluorophenyl)-3H-1,2,3-oxadiazol-1-ium-5-olate

Downstream raw materials:

ethyl 4-[4-(4-fluorophenylamino)-2H-1,2,3-triazol-2-yl]benzoate

4-[4-(4-fluorophenylamino)-2H-1,2,3-triazol-2-yl]benzhydrazide

4-[4-(4-fluorophenylamino)-2H-1,2,3-triazol-2-yl]-N²-(4-methylbenzoyl)benzhydrazide

4-[4-(4-fluorophenylamino)-2H-1,2,3-triazol-2-yl]-N²-(4-chlorobenzoyl)benzhydrazide