N^ε-10-methylpteroyl)-L-glutamyl>-γ-L-lysyl-L-lysine trifluoroacetate

Base Information

Chemical Name:N^ε-10-methylpteroyl)-L-glutamyl>-γ-L-lysyl-L-lysine trifluoroacetate
CAS No.:89637-87-6
Molecular Formula:14C₂HF₃O₂*5C₃₂H₄₆N₁₂O₇
Molecular Weight:5150.3
Hs Code.:

N<sup>ε</sup>-<N-(4-amino-4-deoxy-N<sup>10</sup>-methylpteroyl)-L-glutamyl>-γ-L-lysyl-L-lysine trifluoroacetate

Synonyms:N^ε-10-methylpteroyl)-L-glutamyl>-γ-L-lysyl-L-lysine trifluoroacetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N^ε-10-methylpteroyl)-L-glutamyl>-γ-L-lysyl-L-lysine trifluoroacetate

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Technology Process of N^ε-10-methylpteroyl)-L-glutamyl>-γ-L-lysyl-L-lysine trifluoroacetate

There total 9 articles about N^ε-10-methylpteroyl)-L-glutamyl>-γ-L-lysyl-L-lysine trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 89637-92-3
N^α-(tert-butyloxycarbonyl)-N^ε-10-methylpteroyl)L-glutamyl>-γ-L-lysyl-N'-(benzyloxycarbonyl)-L-lysine

: 89637-87-6
N^ε-10-methylpteroyl)-L-glutamyl>-γ-L-lysyl-L-lysine trifluoroacetate

Guidance literature:: With methyl-phenyl-thioether; trifluoroacetic acid; for 3.5h; Ambient temperature;
DOI:10.1021/jm00373a014

Reference yield:

: 13030-09-6
1-benzyl L-glutamate

: 89637-87-6
N^ε-10-methylpteroyl)-L-glutamyl>-γ-L-lysyl-L-lysine trifluoroacetate

Guidance literature:: Multi-step reaction with 7 steps

1: 99 percent / Et₃N / benzene / Ambient temperature

2: 1.) diethyl phosphorocyanidate, Et₃N / 1.) DMF, overnight, RT, 2.) DMF, RT, 3 d

3: Et₃N / dimethylformamide / 0.33 h / Ambient temperature

4: dimethylformamide / Ambient temperature

5: 79 percent / diphenylphosphoryl azide, Et₃N / dimethylformamide / 0 - 20 °C

6: 86 percent / Ba(OH)2*8H₂O / ethanol; H₂O / Ambient temperature

7: 77 percent / CF₃CO₂H, thioanisole / 3.5 h / Ambient temperature

With barium dihydroxide; diethyl cyanophosphonate; methyl-phenyl-thioether; diphenylphosphoranyl azide; triethylamine; trifluoroacetic acid; In ethanol; water; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00373a014

Reference yield:

: 13734-28-6
Boc-Lys-OH

: 89637-87-6
N^ε-10-methylpteroyl)-L-glutamyl>-γ-L-lysyl-L-lysine trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1: 99 percent / Et₃N / benzene / Ambient temperature

2: dimethylformamide / Ambient temperature

3: 79 percent / diphenylphosphoryl azide, Et₃N / dimethylformamide / 0 - 20 °C

4: 86 percent / Ba(OH)2*8H₂O / ethanol; H₂O / Ambient temperature

5: 77 percent / CF₃CO₂H, thioanisole / 3.5 h / Ambient temperature

With barium dihydroxide; methyl-phenyl-thioether; diphenylphosphoranyl azide; triethylamine; trifluoroacetic acid; In ethanol; water; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00373a014