(S)-3-Acetyl-2-tert-butoxycarbonylamino-4-[(E)-hydroxyimino]-pentanoic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Base Information

Chemical Name:(S)-3-Acetyl-2-tert-butoxycarbonylamino-4-[(E)-hydroxyimino]-pentanoic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester
CAS No.:154108-97-1
Molecular Formula:C₂₂H₃₈N₂O₆
Molecular Weight:426.554
Hs Code.:

Synonyms:(S)-3-Acetyl-2-tert-butoxycarbonylamino-4-[(E)-hydroxyimino]-pentanoic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

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Chemical Property of (S)-3-Acetyl-2-tert-butoxycarbonylamino-4-[(E)-hydroxyimino]-pentanoic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

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Technology Process of (S)-3-Acetyl-2-tert-butoxycarbonylamino-4-[(E)-hydroxyimino]-pentanoic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

There total 6 articles about (S)-3-Acetyl-2-tert-butoxycarbonylamino-4-[(E)-hydroxyimino]-pentanoic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 154108-95-9
(1R,3R,4S)-menthyl (2S)-N-t-BOC-3-acetyl-4-oxonorvaline

: 154108-97-1
(S)-3-Acetyl-2-tert-butoxycarbonylamino-4-[(E)-hydroxyimino]-pentanoic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Guidance literature:: With hydroxylamine; In diethyl ether;
DOI:10.1016/S0040-4039(00)61614-3

Reference yield:

: 2216-51-5
(-)-menthol

: 154108-97-1
(S)-3-Acetyl-2-tert-butoxycarbonylamino-4-[(E)-hydroxyimino]-pentanoic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: TsOH / toluene / Heating

2: NH₃ / dimethylformamide; H₂O

3: CHCl₃ / Heating

4: NBS / CCl₄ / Heating; Irradiation

5: 25 percent / CHCl₃ / Ambient temperature

6: 94 percent / hydroxylamine / diethyl ether

With N-Bromosuccinimide; ammonia; hydroxylamine; toluene-4-sulfonic acid; In tetrachloromethane; diethyl ether; chloroform; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4039(00)61614-3

Reference yield:

: 63254-60-4,80655-94-3,120143-37-5
(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-aminoacetate

: 154108-97-1
(S)-3-Acetyl-2-tert-butoxycarbonylamino-4-[(E)-hydroxyimino]-pentanoic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: CHCl₃ / Heating

2: NBS / CCl₄ / Heating; Irradiation

3: 25 percent / CHCl₃ / Ambient temperature

4: 94 percent / hydroxylamine / diethyl ether

With N-Bromosuccinimide; hydroxylamine; In tetrachloromethane; diethyl ether; chloroform;
DOI:10.1016/S0040-4039(00)61614-3