3-[bis(benzotriazol-1-yl)methyl]-5-phenylisooxazole

Base Information

• Chemical Name: 3-[bis(benzotriazol-1-yl)methyl]-5-phenylisooxazole
• CAS No.: 887652-15-5
• Molecular Formula: C₂₂H₁₅N₇O
• Molecular Weight: 393.407
• Mol file: 887652-15-5.mol

Synonyms:3-[bis(benzotriazol-1-yl)methyl]-5-phenylisooxazole

Chemical Property of 3-[bis(benzotriazol-1-yl)methyl]-5-phenylisooxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 3-[bis(benzotriazol-1-yl)methyl]-5-phenylisooxazole

There total 6 articles about 3-[bis(benzotriazol-1-yl)methyl]-5-phenylisooxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

2,2-bis(benzotriazol-1-yl)-1-chloro-1-(hydroxyimino)-ethane (887652-08-6) + phenylacetylene (536-74-3) → 3-[bis(benzotriazol-1-yl)methyl]-5-phenylisooxazole (887652-15-5)

Guidance literature:

With potassium hydrogencarbonate; In water; ethyl acetate; at 20 ℃; for 16h;

DOI:10.1071/CH05189

Reference yield:

2,2-bis(benzotriazol-1-yl)-1-(hydroxyimino)ethane (887652-07-5) → 3-[bis(benzotriazol-1-yl)methyl]-5-phenylisooxazole (887652-15-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / N-chlorosuccinimide; HCl / dimethylformamide / 20 - 35 °C

2: 48 percent / potassium hydrogen carbonate / ethyl acetate; H₂O / 16 h / 20 °C

With hydrogenchloride; N-chloro-succinimide; potassium hydrogencarbonate; In water; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1071/CH05189

Reference yield:

2,2-bis(benzotriazol-1-yl)-1,1-dihydroxyethane (887652-06-4) → 3-[bis(benzotriazol-1-yl)methyl]-5-phenylisooxazole (887652-15-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / hydroxylamine hydrochloride; sodium acetate trihydrate / H₂O; ethanol / 5 h / 75 °C

2: 100 percent / N-chlorosuccinimide; HCl / dimethylformamide / 20 - 35 °C

3: 48 percent / potassium hydrogen carbonate / ethyl acetate; H₂O / 16 h / 20 °C

With hydrogenchloride; N-chloro-succinimide; hydroxylamine hydrochloride; sodium acetate; potassium hydrogencarbonate; In ethanol; water; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1071/CH05189

upstream raw materials:

2,2-bis(benzotriazol-1-yl)-1-chloro-1-(hydroxyimino)-ethane

phenylacetylene

2,2-bis(benzotriazol-1-yl)-1-(hydroxyimino)ethane

2,2-bis(benzotriazol-1-yl)-1,1-dihydroxyethane

Downstream raw materials:

3-methyl-5-phenylisoxazole