3-METHYL-5-PHENYLISOXAZOLE

Base Information

• Chemical Name: 3-METHYL-5-PHENYLISOXAZOLE
• CAS No.: 1008-75-9
• Molecular Formula: C10H9 N O
• Molecular Weight: 159.188
• Hs Code.: 29349990
• Mol file: 1008-75-9.mol

Synonyms:3-Methyl-5-phenylisoxazole;NSC 80670

Chemical Property of 3-METHYL-5-PHENYLISOXAZOLE

Chemical Property:

• Vapor Pressure: 0.00668mmHg at 25°C
• Melting Point: 63-68 °C
• Boiling Point: 262-264 °C/760 mmHg
• PKA: -2.38±0.28(Predicted)
• Flash Point: 112.7°C
• PSA: 26.03000
• Density: 1.082g/cm³
• LogP: 2.65000
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

3-Methyl-5-phenylisoxazole ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 3-Methyl-5-phenylisoxazole can be used for Aminopeptidase A inhibitors.

Technology Process of 3-METHYL-5-PHENYLISOXAZOLE

There total 104 articles about 3-METHYL-5-PHENYLISOXAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-phenylbutan-1,3-dione (93-91-4) → 3-methyl-5-phenylisoxazole (1008-75-9)

Guidance literature:

With pyridine; hydroxylamine hydrochloride; In water; at 50 ℃; for 3.5h; Inert atmosphere; Schlenk technique;

DOI:10.1021/ol502667h

Reference yield: 100.0%

Nitroethane (79-24-3) + phenylacetylene (536-74-3) → 3-methyl-5-phenylisoxazole (1008-75-9)

Guidance literature:

With dmap; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In acetonitrile; at 80 ℃; for 0.05h; microwave irradiation;

DOI:10.1016/S0040-4020(03)00859-7

Reference yield: 92.0%

4-phenylbut-3-yn-2-one oxime (28164-29-6) → 3-methyl-5-phenylisoxazole (1008-75-9)

Guidance literature:

With gold(III) chloride; In dichloromethane; at 30 ℃; for 0.166667h; Inert atmosphere;

DOI:10.1007/s12039-015-0993-9

upstream raw materials:

formic acid

1-phenyl-1,3-pentanedionedioxime

N-(1-Hydroxyimino-1-phenyl-3-butyl)hydroxylamine

N-hydroxy-N-(1-methyl-3-oxo-3-phenyl-propyl)-formamide

Downstream raw materials:

3-methyl-5-(4-nitrophenyl)isoxazole

3-amino-1-phenylbut-2-en-1-one

3-methyl-5-phenylpyrazole

Verbdg_. s.n.F