N-benzyl-3-(4-chlorophenyl)-N-(2-iodo-4-methylphenyl)-3-oxopropanamide

Base Information

• Chemical Name: N-benzyl-3-(4-chlorophenyl)-N-(2-iodo-4-methylphenyl)-3-oxopropanamide
• CAS No.: 922142-37-8
• Molecular Formula: C₂₃H₁₉ClINO₂
• Molecular Weight: 503.767
• Mol file: 922142-37-8.mol

Synonyms:N-benzyl-3-(4-chlorophenyl)-N-(2-iodo-4-methylphenyl)-3-oxopropanamide

Chemical Property of N-benzyl-3-(4-chlorophenyl)-N-(2-iodo-4-methylphenyl)-3-oxopropanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzyl-3-(4-chlorophenyl)-N-(2-iodo-4-methylphenyl)-3-oxopropanamide

There total 2 articles about N-benzyl-3-(4-chlorophenyl)-N-(2-iodo-4-methylphenyl)-3-oxopropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-benzoyl chloride (122-01-0) → N-benzyl-3-(4-chlorophenyl)-N-(2-iodo-4-methylphenyl)-3-oxopropanamide (922142-37-8)

Guidance literature:

Multi-step reaction with 2 steps

1: DMAP / CH₂Cl₂ / 0 - 20 °C

2: dioxane / 1 h / Heating

With dmap; In 1,4-dioxane; dichloromethane;

DOI:10.1021/ol0625886

Reference yield:

N-benzyl-2-iodo-4-methylaniline + 5-(4-Chloro-benzoyl)-2,2-dimethyl-[1,3]dioxane-4,6-dione (112378-38-8) → N-benzyl-3-(4-chlorophenyl)-N-(2-iodo-4-methylphenyl)-3-oxopropanamide (922142-37-8)

Guidance literature:

In 1,4-dioxane; for 1h; Heating;

DOI:10.1021/ol0625886

Reference yield: 71.0%

N-benzyl-3-(4-chlorophenyl)-N-(2-iodo-4-methylphenyl)-3-oxopropanamide (922142-37-8) → 1-benzyl-3-[(4-chloro-phenyl)-hydroxy-methylene]-5-methyl-1,3-dihydro-indol-2-one

Guidance literature:

With copper(l) iodide; caesium carbonate; L-proline; In dimethyl sulfoxide; at 20 ℃;

DOI:10.1021/ol0625886

upstream raw materials:

5-(4-Chloro-benzoyl)-2,2-dimethyl-[1,3]dioxane-4,6-dione

4-chloro-benzoyl chloride