{[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-ethyl]-[2-(4-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-2-oxo-2H-pyrimidin-1-yl)-acetyl]-amino}-acetic acid methyl ester

Base Information

• Chemical Name: {[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-ethyl]-[2-(4-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-2-oxo-2H-pyrimidin-1-yl)-acetyl]-amino}-acetic acid methyl ester
• CAS No.: 172405-58-2
• Molecular Formula: C₄₆H₄₃N₅O₇
• Molecular Weight: 777.877

Synonyms:{[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-ethyl]-[2-(4-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-2-oxo-2H-pyrimidin-1-yl)-acetyl]-amino}-acetic acid methyl ester

Chemical Property of {[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-ethyl]-[2-(4-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-2-oxo-2H-pyrimidin-1-yl)-acetyl]-amino}-acetic acid methyl ester

Chemical Property:

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Technology Process of {[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-ethyl]-[2-(4-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-2-oxo-2H-pyrimidin-1-yl)-acetyl]-amino}-acetic acid methyl ester

There total 6 articles about {[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-ethyl]-[2-(4-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-2-oxo-2H-pyrimidin-1-yl)-acetyl]-amino}-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

[N4-(4-methoxytrityl)-cyrosin-1-yl]-acetic acid (172405-54-8) + N-(2-{[(9H-fluoren-9-yl)methoxy]carbonylamino}ethyl)-2-methoxy-2-oxoethanaminium chloride → {[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-ethyl]-[2-(4-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-2-oxo-2H-pyrimidin-1-yl)-acetyl]-amino}-acetic acid methyl ester (172405-58-2)

Guidance literature:

With O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 3h; Ambient temperature;

DOI:10.1016/0960-894X(96)00082-0

Reference yield:

9-fluorenylmethyl N-succinimidyl carbonate (102774-86-7) → {[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-ethyl]-[2-(4-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-2-oxo-2H-pyrimidin-1-yl)-acetyl]-amino}-acetic acid methyl ester (172405-58-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / dioxane; H₂O

2: 82 percent / O-<(cyano(ethoxycarbonyl)methylen)amino>-1,1,3,3-tetramethyluronium-tetrafluoroborate, diisopropylethylamine / dimethylformamide / 3 h / Ambient temperature

With O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; water; N,N-dimethyl-formamide;

DOI:10.1016/0960-894X(96)00082-0

Reference yield:

N-(2-aminoethyl)glycine methyl ester dihydrochloride → {[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-ethyl]-[2-(4-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-2-oxo-2H-pyrimidin-1-yl)-acetyl]-amino}-acetic acid methyl ester (172405-58-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / dioxane; H₂O

2: 82 percent / O-<(cyano(ethoxycarbonyl)methylen)amino>-1,1,3,3-tetramethyluronium-tetrafluoroborate, diisopropylethylamine / dimethylformamide / 3 h / Ambient temperature

With O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; water; N,N-dimethyl-formamide;

DOI:10.1016/0960-894X(96)00082-0

upstream raw materials:

[N⁴-(4-methoxytrityl)-cyrosin-1-yl]-acetic acid

9-fluorenylmethyl N-succinimidyl carbonate

N⁴-[(4-methoxyphenyl)diphenylmethyl]cytosine

methyl [N⁴-(4-methoxytrityl)-cytosin-1-yl]-acetate

Downstream raw materials:

{[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-ethyl]-[2-(4-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-2-oxo-2H-pyrimidin-1-yl)-acetyl]-amino}-acetic acid

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