102774-86-7

Basic information

• Product Name: 9H-fluoren-9-ylmethyl 2,5-dioxopyrrolidine-1-carboxylate
• Synonyms: 9H-Fluoren-9-ylmethyl 2,5-dioxopyrrolidine-1-carboxylate
• CAS NO: 102774-86-7
• Molecular Formula: C₁₉H₁₅NO₄
• Molecular Weight: 321.3267
• Mol File: 102774-86-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 495.1°C at 760 mmHg
• Flash Point: 253.2°C
• Density: 1.368g/cm³
• Vapor Pressure: 6.06E-10mmHg at 25°C
• Refractive Index: 1.644
• CAS DataBase Reference: 9H-fluoren-9-ylmethyl 2,5-dioxopyrrolidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 9H-fluoren-9-ylmethyl 2,5-dioxopyrrolidine-1-carboxylate(102774-86-7)
• EPA Substance Registry System: 9H-fluoren-9-ylmethyl 2,5-dioxopyrrolidine-1-carboxylate(102774-86-7)

Safety Data

• Hazardous Substances Data: 102774-86-7(Hazardous Substances Data)

Usage

Description

9H-fluoren-9-ylmethyl 2,5-dioxopyrrolidine-1-carboxylate is a versatile chemical compound utilized as a building block in organic synthesis. It features a fluorene moiety and a pyrrolidine-2,5-dione ester, which contribute to its structural flexibility and potential for biological activity. This molecule's unique structure and reactivity make it a promising candidate for various applications in the fields of organic chemistry and material science.

Uses

Used in Pharmaceutical Industry:
9H-fluoren-9-ylmethyl 2,5-dioxopyrrolidine-1-carboxylate is used as a precursor for creating potential drug candidates due to its structural flexibility and potential for biological activity. Its unique molecular structure allows for the development of new compounds with therapeutic properties.
Used in Material Science:
In the field of material science, 9H-fluoren-9-ylmethyl 2,5-dioxopyrrolidine-1-carboxylate is used as a component in the production of advanced materials such as polymers and dyes. Its distinctive structure and reactivity enable the creation of materials with specific properties, making it valuable for various applications.
Used in Organic Chemistry Research:
9H-fluoren-9-ylmethyl 2,5-dioxopyrrolidine-1-carboxylate is used as a research tool in organic chemistry to explore new synthetic pathways and reactions. Its unique structure provides opportunities for the development of novel chemical processes and the discovery of new compounds with potential applications in various industries.

Upstream product

• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 

Downstream Products

• 71989-33-8 Fmoc-Ser(tBu)-OH 
• 136590-09-5 (S)-3-(3-nitro-4-hydroxyphenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionic acid 
• 302567-98-2 (9H-fluoren-9-yl)methyl (4-methoxyphenyl)carbamate 
• 289706-29-2 3'-deoxy-5'-O-(4,4'-dimethoxytrityl)-3'-{{6-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-1-oxohexyl}amino}thymidine 
• 289706-30-5 3'-deoxy-5'-O-(4,4'-dimethoxytrityl)-3'-{{6-{[(9H)-(fluoren-9-ylmethoxy)carbonyl]-amino}-1-thioxohexyl}amino}thymidine 
• 136083-57-3 N-α-9-fluorenylmethoxycarbonyl-aspartic acid 
• 908846-88-8 (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(5-fluoro-1H-indol-3-yl)-propanoic acid 
• 460751-69-3 (S)-N-(fluoren-9-ylmethoxycarbonyl)-5-methoxy-tryptophan 
• 169396-88-7 tert-butyl N-[2-(N-9-fluorenylmethoxycarbonyl)aminoethyl]glycinate hydrochloride 
• 751470-47-0 (R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-sulfopropanoic acid 
• 437655-95-3 [2-(2-{2-[2-((9H-fluoren-9-yl-methoxycarbonyl)amino)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-acetic acid 
• 851909-08-5 (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)hex-5-enoic acid 
• 538372-74-6 C₂₁H₂₀⁽²⁾H₃NO₄ 
• 1068435-19-7 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-2-(pent-4-enyl)hept-6-enoic acid 

Relevant articles and documents

Production and cogeneration N [...] succinimide, N '-di-succinimide-based carbon ester method

The invention belongs to the field of fine chemical engineering, and particularly relates to a method for producing fluorenylmethoxycarbonylacyl succinimide and coproducing N,N'-disuccinimidocarbonate. The method comprises the following steps: (1) preparation of Fmoc-cl: adding THF (tetrahydrofuran), 9-fluorenylmethanol and an organic amine catalyst into a reaction kettle, cooling to 0-10 DEG C, adding solid phosgene, and completely reacting; (2) preparation of Fmoc-Osu and DSC: adding Hosu, cooling to -5 to +5 DEG C, dropwisely adding a tributyl amine tetrahydrofuran solution, heating to room temperature, and completely reacting; (3) filtering to obtain a DSC crude product; and (4) carrying out mother solution after-treatment to obtain the Fmoc-Osu. A proper amount of 9-fluorenylmethanol is added into the Hosu/solid phosgene/tributyl amine system to quantitatively generate the two products Fmoc-Osu and DSC, wherein the DSC precipitates in the form of crystalline solid, and the Fmoc-Osu and tributyl amine hydrochloride are still dissolved in the tetrahydrofuran solvent; and therefore, the two products can be respectively subjected to filtration, purification and other routine operations to obtain the refined products with the purity of greater than 99%.