18-(4-fluorophenyl)-3,11,12,13,14,16,17,18-octahydro-10H-2,15-(azeno)-4,8-(metheno)cyciopenta[h][1,4,10,12]oxatriazacycloheptadecine-7-carbonitrile

Base Information

Chemical Name:18-(4-fluorophenyl)-3,11,12,13,14,16,17,18-octahydro-10H-2,15-(azeno)-4,8-(metheno)cyciopenta[h][1,4,10,12]oxatriazacycloheptadecine-7-carbonitrile
CAS No.:1356008-78-0
Molecular Formula:C₂₄H₂₂FN₅O
Molecular Weight:415.47
Hs Code.:

18-(4-fluorophenyl)-3,11,12,13,14,16,17,18-octahydro-10H-2,15-(azeno)-4,8-(metheno)cyciopenta[h][1,4,10,12]oxatriazacycloheptadecine-7-carbonitrile

Synonyms:18-(4-fluorophenyl)-3,11,12,13,14,16,17,18-octahydro-10H-2,15-(azeno)-4,8-(metheno)cyciopenta[h][1,4,10,12]oxatriazacycloheptadecine-7-carbonitrile

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Chemical Property of 18-(4-fluorophenyl)-3,11,12,13,14,16,17,18-octahydro-10H-2,15-(azeno)-4,8-(metheno)cyciopenta[h][1,4,10,12]oxatriazacycloheptadecine-7-carbonitrile

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Technology Process of 18-(4-fluorophenyl)-3,11,12,13,14,16,17,18-octahydro-10H-2,15-(azeno)-4,8-(metheno)cyciopenta[h][1,4,10,12]oxatriazacycloheptadecine-7-carbonitrile

There total 14 articles about 18-(4-fluorophenyl)-3,11,12,13,14,16,17,18-octahydro-10H-2,15-(azeno)-4,8-(metheno)cyciopenta[h][1,4,10,12]oxatriazacycloheptadecine-7-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1356010-61-1
tert-butyl 7-cyano-18-(4-fluorophenyl)-10,11,14,16,17,18-hexahydro-3H-15,2-(azeno)-4,8-(metheno)cyclopenta[h][1,4,10,12]oxatriazacycloheptadecine-12(13H)-carboxylate

: 1356008-78-0
18-(4-fluorophenyl)-3,11,12,13,14,16,17,18-octahydro-10H-2,15-(azeno)-4,8-(metheno)cyciopenta[h][1,4,10,12]oxatriazacycloheptadecine-7-carbonitrile

Guidance literature:: tert-butyl 7-cyano-18-(4-fluorophenyl)-10,11,14,16,17,18-hexahydro-3H-15,2-(azeno)-4,8-(metheno)cyclopenta[h][1,4,10,12]oxatriazacycloheptadecine-12(13H)-carboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h; Cooling with ice;

With sodium hydrogencarbonate;

Reference yield:

: 120-92-3
cyclopentanone

: 1356008-78-0
18-(4-fluorophenyl)-3,11,12,13,14,16,17,18-octahydro-10H-2,15-(azeno)-4,8-(metheno)cyciopenta[h][1,4,10,12]oxatriazacycloheptadecine-7-carbonitrile

Guidance literature:: Multi-step reaction with 10 steps

1.1: diethyl ether; tetrahydrofuran / 2 h / 0 °C / Reflux

2.1: formic acid; dihydrogen peroxide / 20 - 50 °C

3.1: 3 h / 58 - 130 °C

4.1: ammonium hydroxide / 100 °C

5.1: trichlorophosphate; N,N-dimethyl-aniline / 110 °C

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 2 h / 110 °C / Inert atmosphere

6.2: 18 h / 75 °C

7.1: triethylamine / dichloromethane / 1 h / 20 °C

8.1: ammonium chloride; iron / water; methanol / 2.5 h / 65 °C

9.1: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 1 h / 110 °C / Inert atmosphere

10.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C / Cooling with ice

With ammonium hydroxide; formic acid; dihydrogen peroxide; iron; ammonium chloride; caesium carbonate; N,N-dimethyl-aniline; triethylamine; trifluoroacetic acid; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; water; toluene;

Reference yield:

: 39835-14-8
2-hydroxy-4-nitro-benzonitrile

: 1356008-78-0
18-(4-fluorophenyl)-3,11,12,13,14,16,17,18-octahydro-10H-2,15-(azeno)-4,8-(metheno)cyciopenta[h][1,4,10,12]oxatriazacycloheptadecine-7-carbonitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 90 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 2 h / 110 °C / Inert atmosphere

3.2: 18 h / 75 °C

4.1: triethylamine / dichloromethane / 1 h / 20 °C

5.1: ammonium chloride; iron / water; methanol / 2.5 h / 65 °C

6.1: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 1 h / 110 °C / Inert atmosphere

7.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C / Cooling with ice

With iron; ammonium chloride; caesium carbonate; triethylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;