tert-butyl 7-cyano-18-(4-fluorophenyl)-10,11,14,16,17,18-hexahydro-3H-15,2-(azeno)-4,8-(metheno)cyclopenta[h][1,4,10,12]oxatriazacycloheptadecine-12(13H)-carboxylate

Base Information

Chemical Name:tert-butyl 7-cyano-18-(4-fluorophenyl)-10,11,14,16,17,18-hexahydro-3H-15,2-(azeno)-4,8-(metheno)cyclopenta[h][1,4,10,12]oxatriazacycloheptadecine-12(13H)-carboxylate
CAS No.:1356010-61-1
Molecular Formula:C₂₉H₃₀FN₅O₃
Molecular Weight:515.587
Hs Code.:

tert-butyl 7-cyano-18-(4-fluorophenyl)-10,11,14,16,17,18-hexahydro-3H-15,2-(azeno)-4,8-(metheno)cyclopenta[h][1,4,10,12]oxatriazacycloheptadecine-12(13H)-carboxylate

Synonyms:tert-butyl 7-cyano-18-(4-fluorophenyl)-10,11,14,16,17,18-hexahydro-3H-15,2-(azeno)-4,8-(metheno)cyclopenta[h][1,4,10,12]oxatriazacycloheptadecine-12(13H)-carboxylate

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Chemical Property of tert-butyl 7-cyano-18-(4-fluorophenyl)-10,11,14,16,17,18-hexahydro-3H-15,2-(azeno)-4,8-(metheno)cyclopenta[h][1,4,10,12]oxatriazacycloheptadecine-12(13H)-carboxylate

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Technology Process of tert-butyl 7-cyano-18-(4-fluorophenyl)-10,11,14,16,17,18-hexahydro-3H-15,2-(azeno)-4,8-(metheno)cyclopenta[h][1,4,10,12]oxatriazacycloheptadecine-12(13H)-carboxylate

There total 12 articles about tert-butyl 7-cyano-18-(4-fluorophenyl)-10,11,14,16,17,18-hexahydro-3H-15,2-(azeno)-4,8-(metheno)cyclopenta[h][1,4,10,12]oxatriazacycloheptadecine-12(13H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 120-92-3
cyclopentanone

: 1356010-61-1
tert-butyl 7-cyano-18-(4-fluorophenyl)-10,11,14,16,17,18-hexahydro-3H-15,2-(azeno)-4,8-(metheno)cyclopenta[h][1,4,10,12]oxatriazacycloheptadecine-12(13H)-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: diethyl ether; tetrahydrofuran / 2 h / 0 °C / Reflux

2.1: formic acid; dihydrogen peroxide / 20 - 50 °C

3.1: 3 h / 58 - 130 °C

4.1: ammonium hydroxide / 100 °C

5.1: trichlorophosphate; N,N-dimethyl-aniline / 110 °C

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 2 h / 110 °C / Inert atmosphere

6.2: 18 h / 75 °C

7.1: triethylamine / dichloromethane / 1 h / 20 °C

8.1: ammonium chloride; iron / water; methanol / 2.5 h / 65 °C

9.1: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 1 h / 110 °C / Inert atmosphere

With ammonium hydroxide; formic acid; dihydrogen peroxide; iron; ammonium chloride; caesium carbonate; N,N-dimethyl-aniline; triethylamine; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; water; toluene;

Reference yield:

: 39835-14-8
2-hydroxy-4-nitro-benzonitrile

: 1356010-61-1
tert-butyl 7-cyano-18-(4-fluorophenyl)-10,11,14,16,17,18-hexahydro-3H-15,2-(azeno)-4,8-(metheno)cyclopenta[h][1,4,10,12]oxatriazacycloheptadecine-12(13H)-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 90 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 2 h / 110 °C / Inert atmosphere

3.2: 18 h / 75 °C

4.1: triethylamine / dichloromethane / 1 h / 20 °C

5.1: ammonium chloride; iron / water; methanol / 2.5 h / 65 °C

6.1: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 1 h / 110 °C / Inert atmosphere

With iron; ammonium chloride; caesium carbonate; triethylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 352-13-6
4-flourophenylmagnesium bromide

: 1356010-61-1
tert-butyl 7-cyano-18-(4-fluorophenyl)-10,11,14,16,17,18-hexahydro-3H-15,2-(azeno)-4,8-(metheno)cyclopenta[h][1,4,10,12]oxatriazacycloheptadecine-12(13H)-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: diethyl ether; tetrahydrofuran / 2 h / 0 °C / Reflux

2.1: formic acid; dihydrogen peroxide / 20 - 50 °C

3.1: 3 h / 58 - 130 °C

4.1: ammonium hydroxide / 100 °C

5.1: trichlorophosphate; N,N-dimethyl-aniline / 110 °C

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 2 h / 110 °C / Inert atmosphere

6.2: 18 h / 75 °C

7.1: triethylamine / dichloromethane / 1 h / 20 °C

8.1: ammonium chloride; iron / water; methanol / 2.5 h / 65 °C

9.1: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 1 h / 110 °C / Inert atmosphere

With ammonium hydroxide; formic acid; dihydrogen peroxide; iron; ammonium chloride; caesium carbonate; N,N-dimethyl-aniline; triethylamine; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; water; toluene;