2-{[(2S)-2-({(2R)-2-[4-benzyloxy-3-(2-hydroxyethyl)phenyl]-2-hydroxyethyl}amino)-1,2,3,4-tetrahydronaphthalen-7-yl]oxy}-N,N-dimethylacetamide

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Chemical Name:2-{[(2S)-2-({(2R)-2-[4-benzyloxy-3-(2-hydroxyethyl)phenyl]-2-hydroxyethyl}amino)-1,2,3,4-tetrahydronaphthalen-7-yl]oxy}-N,N-dimethylacetamide
CAS No.:371783-92-5
Molecular Formula:C₃₁H₃₈N₂O₅
Molecular Weight:518.653
Hs Code.:

Synonyms:2-{[(2S)-2-({(2R)-2-[4-benzyloxy-3-(2-hydroxyethyl)phenyl]-2-hydroxyethyl}amino)-1,2,3,4-tetrahydronaphthalen-7-yl]oxy}-N,N-dimethylacetamide

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Chemical Property of 2-{[(2S)-2-({(2R)-2-[4-benzyloxy-3-(2-hydroxyethyl)phenyl]-2-hydroxyethyl}amino)-1,2,3,4-tetrahydronaphthalen-7-yl]oxy}-N,N-dimethylacetamide

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Technology Process of 2-{[(2S)-2-({(2R)-2-[4-benzyloxy-3-(2-hydroxyethyl)phenyl]-2-hydroxyethyl}amino)-1,2,3,4-tetrahydronaphthalen-7-yl]oxy}-N,N-dimethylacetamide

There total 15 articles about 2-{[(2S)-2-({(2R)-2-[4-benzyloxy-3-(2-hydroxyethyl)phenyl]-2-hydroxyethyl}amino)-1,2,3,4-tetrahydronaphthalen-7-yl]oxy}-N,N-dimethylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 371783-91-4
2-{[(2S)-2-({(2R)-2-[4-benzyloxy-3-(2-tert-butyldimethylsilyloxyethyl)phenyl]-2-tert-butyldimethylsilyloxyethyl}amino)-1,2,3,4-tetrahydronaphthalen-7-yl]oxy}-N,N-dimethylacetamide

: 371783-92-5
2-{[(2S)-2-({(2R)-2-[4-benzyloxy-3-(2-hydroxyethyl)phenyl]-2-hydroxyethyl}amino)-1,2,3,4-tetrahydronaphthalen-7-yl]oxy}-N,N-dimethylacetamide

Guidance literature:: With toluene-4-sulfonic acid; In tetrahydrofuran; at 20 ℃;
DOI:10.1248/cpb.49.1018

Reference yield:

: 24085-05-0
1-(3-chloromethyl-4-hydroxyphenyl)ethanone

: 371783-92-5
2-{[(2S)-2-({(2R)-2-[4-benzyloxy-3-(2-hydroxyethyl)phenyl]-2-hydroxyethyl}amino)-1,2,3,4-tetrahydronaphthalen-7-yl]oxy}-N,N-dimethylacetamide

Guidance literature:: Multi-step reaction with 9 steps

1: dimethylsulfoxide / 1 h / 60 °C

2: aq. NaOH / 2 h / Heating

3: 87 percent / H₂SO₄ / 1 h / Heating

4: 78 percent / KI; K₂CO₃ / dimethylformamide / 1.5 h / 50 °C

5: 72 percent / Br₂ / hexane; ethyl acetate / 0.5 h

6: 86 percent / Al(OEt)3; (R)-α,α-diphenyl-2-pyrrolidinylmethanol; BH3*Me2S / tetrahydrofuran / 2 h / 50 °C

7: imidazole / toluene; dimethylformamide / 8 h / 20 °C

8: K₂CO₃ / N,N-dimethyl-acetamide / 6 h / Heating

9: aq. TsOH / tetrahydrofuran / 20 °C

With 1H-imidazole; sodium hydroxide; dimethylsulfide borane complex; sulfuric acid; bromine; aluminum ethoxide; potassium carbonate; (R)-α,α-diphenylprolinol; toluene-4-sulfonic acid; potassium iodide; In tetrahydrofuran; hexane; N,N-dimethyl acetamide; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1248/cpb.49.1018

Reference yield:

: 65236-06-8
5-acetyl-2-hydroxyphenylacetonitrile

: 371783-92-5
2-{[(2S)-2-({(2R)-2-[4-benzyloxy-3-(2-hydroxyethyl)phenyl]-2-hydroxyethyl}amino)-1,2,3,4-tetrahydronaphthalen-7-yl]oxy}-N,N-dimethylacetamide

Guidance literature:: Multi-step reaction with 8 steps

1: aq. NaOH / 2 h / Heating

2: 87 percent / H₂SO₄ / 1 h / Heating

3: 78 percent / KI; K₂CO₃ / dimethylformamide / 1.5 h / 50 °C

4: 72 percent / Br₂ / hexane; ethyl acetate / 0.5 h

5: 86 percent / Al(OEt)3; (R)-α,α-diphenyl-2-pyrrolidinylmethanol; BH3*Me2S / tetrahydrofuran / 2 h / 50 °C

6: imidazole / toluene; dimethylformamide / 8 h / 20 °C

7: K₂CO₃ / N,N-dimethyl-acetamide / 6 h / Heating

8: aq. TsOH / tetrahydrofuran / 20 °C

With 1H-imidazole; sodium hydroxide; dimethylsulfide borane complex; sulfuric acid; bromine; aluminum ethoxide; potassium carbonate; (R)-α,α-diphenylprolinol; toluene-4-sulfonic acid; potassium iodide; In tetrahydrofuran; hexane; N,N-dimethyl acetamide; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1248/cpb.49.1018