(S)-2-(4-{4-[4-(4-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyrylamino)-butyrylamino]-butyrylamino}-butyrylamino)-pentanedioic acid

Base Information

Chemical Name:(S)-2-(4-{4-[4-(4-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyrylamino)-butyrylamino]-butyrylamino}-butyrylamino)-pentanedioic acid
CAS No.:103321-31-9
Molecular Formula:C₃₆H₅₀N₁₂O₉
Molecular Weight:794.868
Hs Code.:

(S)-2-(4-{4-[4-(4-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyrylamino)-butyrylamino]-butyrylamino}-butyrylamino)-pentanedioic acid

Synonyms:(S)-2-(4-{4-[4-(4-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyrylamino)-butyrylamino]-butyrylamino}-butyrylamino)-pentanedioic acid

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Chemical Property of (S)-2-(4-{4-[4-(4-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyrylamino)-butyrylamino]-butyrylamino}-butyrylamino)-pentanedioic acid

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Technology Process of (S)-2-(4-{4-[4-(4-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyrylamino)-butyrylamino]-butyrylamino}-butyrylamino)-pentanedioic acid

There total 9 articles about (S)-2-(4-{4-[4-(4-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyrylamino)-butyrylamino]-butyrylamino}-butyrylamino)-pentanedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 103321-46-6
(S)-2-(4-{4-[4-(4-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyrylamino)-butyrylamino]-butyrylamino}-butyrylamino)-pentanedioic acid di-tert-butyl ester

: 103321-31-9
(S)-2-(4-{4-[4-(4-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyrylamino)-butyrylamino]-butyrylamino}-butyrylamino)-pentanedioic acid

Guidance literature:: With trifluoroacetic acid; for 0.166667h; Ambient temperature;
DOI:10.1021/jm00160a014

Reference yield:

: 1489-76-5
4-(4-Benzyloxycarbonylamino-butyrylamino)-butyric acid

: 103321-31-9
(S)-2-(4-{4-[4-(4-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyrylamino)-butyrylamino]-butyrylamino}-butyrylamino)-pentanedioic acid

Guidance literature:: Multi-step reaction with 7 steps

1: Et₃N / dimethylformamide / 0.33 h

2: Et₃N / dimethylformamide / 0.5 h

3: 97 percent / Ba(OH)2.8H₂O / ethanol; H₂O / Ambient temperature

4: 100 percent / diphenylphosphoryl azide (DPPA), Et₃N / dimethylformamide / Ambient temperature

5: 98 percent / HCl (gas), H₂ / 5percent Pd/C / methanol / 1 h

6: 1.) diethyl phosphorocyanidate (DEPC), Et₃N, 2.) Et₃N / 1.) DMF, 2.) DMF, 3 days

7: 90 percent / CF₃COOH / 0.17 h / Ambient temperature

With hydrogenchloride; barium dihydroxide; diethyl cyanophosphonate; diphenylphosphoranyl azide; hydrogen; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00160a014

Reference yield:

: 90139-76-7
4-(4-Benzyloxycarbonylamino-butyrylamino)-butyric acid methyl ester

: 103321-31-9
(S)-2-(4-{4-[4-(4-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-butyrylamino)-butyrylamino]-butyrylamino}-butyrylamino)-pentanedioic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 97 percent / Ba(OH)2.8H₂O / ethanol; H₂O / Ambient temperature

2: Et₃N / dimethylformamide / 0.33 h

3: Et₃N / dimethylformamide / 0.5 h

4: 97 percent / Ba(OH)2.8H₂O / ethanol; H₂O / Ambient temperature

5: 100 percent / diphenylphosphoryl azide (DPPA), Et₃N / dimethylformamide / Ambient temperature

6: 98 percent / HCl (gas), H₂ / 5percent Pd/C / methanol / 1 h

7: 1.) diethyl phosphorocyanidate (DEPC), Et₃N, 2.) Et₃N / 1.) DMF, 2.) DMF, 3 days

8: 90 percent / CF₃COOH / 0.17 h / Ambient temperature

With hydrogenchloride; barium dihydroxide; diethyl cyanophosphonate; diphenylphosphoranyl azide; hydrogen; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00160a014