(S)-1-Boc-3-benzylpiperazine

Base Information

• Chemical Name: (S)-1-Boc-3-benzylpiperazine
• CAS No.: 475272-55-0
• Molecular Formula: C16H24 N2 O2
• Molecular Weight: 276.379
• Hs Code.: 2933599090
• Mol file: 475272-55-0.mol

Synonyms:(S)-tert-Butyl 3-benzylpiperazine-1-carboxylate

Chemical Property of (S)-1-Boc-3-benzylpiperazine

Chemical Property:

• Vapor Pressure: 5.7E-06mmHg at 25°C
• Refractive Index: 1.524
• Boiling Point: 379.8 °C at 760 mmHg
• PKA: 8.45±0.40(Predicted)
• Flash Point: 183.5 °C
• PSA: 41.57000
• Density: 1.066g/cm³
• LogP: 2.70470
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

(S)-1-Boc-3-benzylpiperazine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-1-Boc-3-benzylpiperazine

There total 1 articles about (S)-1-Boc-3-benzylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C22H27N3O6S → (3S)-3-benzylpiperazine-1-carboxylic acid tert-butyl ester (475272-55-0)

Guidance literature:

With Octanethiol; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 20 ℃; for 0.25h; regioselective reaction;

DOI:10.1021/jo900441s

Reference yield: 100.0%

(3S)-3-benzylpiperazine-1-carboxylic acid tert-butyl ester (475272-55-0) → (2S)-2-benzylpiperazine dihydrochloride (1240595-20-3)

Guidance literature:

With hydrogenchloride; In dichloromethane; at 20 ℃;

DOI:10.1021/jm4016735

Reference yield:

2-chloro-1-phenyl-1H-pyrrolo[3,2-b]pyridine-3-carboxylic acid (1175014-68-2) + (3S)-3-benzylpiperazine-1-carboxylic acid tert-butyl ester (475272-55-0) → C30H31ClN4O3

Guidance literature:

With 4-methyl-morpholine; O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmcl.2011.06.114

Downstream raw materials:

(2S)-2-benzylpiperazine dihydrochloride

(3S)-3-benzyl-1-(2-thiophenylsulfonyl)piperazine

2-(4-((2S)-2-benzyl-4-(2-thiophenylsulfonyl)-1-piperazinyl)-phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

Refernces