2-(4-((2S)-2-benzyl-4-(2-thiophenylsulfonyl)-1-piperazinyl)-phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

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Chemical Name:2-(4-((2S)-2-benzyl-4-(2-thiophenylsulfonyl)-1-piperazinyl)-phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol
CAS No.:1361218-10-1
Molecular Formula:C₂₄H₂₂F₆N₂O₃S₂
Molecular Weight:564.573
Hs Code.:

Synonyms:2-(4-((2S)-2-benzyl-4-(2-thiophenylsulfonyl)-1-piperazinyl)-phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

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Chemical Property of 2-(4-((2S)-2-benzyl-4-(2-thiophenylsulfonyl)-1-piperazinyl)-phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

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Technology Process of 2-(4-((2S)-2-benzyl-4-(2-thiophenylsulfonyl)-1-piperazinyl)-phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

There total 3 articles about 2-(4-((2S)-2-benzyl-4-(2-thiophenylsulfonyl)-1-piperazinyl)-phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 1361218-12-3
(3S)-3-benzyl-1-(2-thiophenylsulfonyl)piperazine

: 2402-72-4
2-(4-bromophenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

: 1361218-10-1
2-(4-((2S)-2-benzyl-4-(2-thiophenylsulfonyl)-1-piperazinyl)-phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate; ruphos; In toluene; at 100 ℃; for 29h; Inert atmosphere;
DOI:10.1021/jm4016735

Reference yield:

: 475272-55-0
(3S)-3-benzylpiperazine-1-carboxylic acid tert-butyl ester

: 1361218-10-1
2-(4-((2S)-2-benzyl-4-(2-thiophenylsulfonyl)-1-piperazinyl)-phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / dichloromethane / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

3: sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ruphos / toluene / 29 h / 100 °C / Inert atmosphere

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine; sodium t-butanolate; ruphos; In dichloromethane; toluene;
DOI:10.1021/jm4016735

Reference yield:

: 1240595-20-3
(2S)-2-benzylpiperazine dihydrochloride

: 1361218-10-1
2-(4-((2S)-2-benzyl-4-(2-thiophenylsulfonyl)-1-piperazinyl)-phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

2: sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ruphos / toluene / 29 h / 100 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine; sodium t-butanolate; ruphos; In dichloromethane; toluene;
DOI:10.1021/jm4016735