Boc-D-Leu-L-Leu-L-threo-O-[Fmoc-L-Ser(OtBu)]-HyPhe-L-HyLeu(OTBS)-L-Leu-OAll

Base Information

Chemical Name:Boc-D-Leu-L-Leu-L-threo-O-[Fmoc-L-Ser(OtBu)]-HyPhe-L-HyLeu(OTBS)-L-Leu-OAll
CAS No.:940301-24-6
Molecular Formula:C₆₉H₁₀₄N₆O₁₄Si
Molecular Weight:1269.7
Hs Code.:

Synonyms:Boc-D-Leu-L-Leu-L-threo-O-[Fmoc-L-Ser(OtBu)]-HyPhe-L-HyLeu(OTBS)-L-Leu-OAll

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Chemical Property of Boc-D-Leu-L-Leu-L-threo-O-[Fmoc-L-Ser(OtBu)]-HyPhe-L-HyLeu(OTBS)-L-Leu-OAll

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Technology Process of Boc-D-Leu-L-Leu-L-threo-O-[Fmoc-L-Ser(OtBu)]-HyPhe-L-HyLeu(OTBS)-L-Leu-OAll

There total 11 articles about Boc-D-Leu-L-Leu-L-threo-O-[Fmoc-L-Ser(OtBu)]-HyPhe-L-HyLeu(OTBS)-L-Leu-OAll which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 940301-23-5
Boc-D-Leu-L-Leu-L-HyPhe-L-HyLeu(OTBS)-L-Leu-OAll

: 71989-33-8
Fmoc-Ser(tBu)-OH

: 940301-24-6
Boc-D-Leu-L-Leu-L-threo-O-[Fmoc-L-Ser(OtBu)]-HyPhe-L-HyLeu(OTBS)-L-Leu-OAll

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;
DOI:10.1021/ja067648h

Reference yield:

: 150211-67-9
Boc-D-Leu-L-Leu-OH

: 940301-24-6
Boc-D-Leu-L-Leu-L-threo-O-[Fmoc-L-Ser(OtBu)]-HyPhe-L-HyLeu(OTBS)-L-Leu-OAll

Guidance literature:: Multi-step reaction with 4 steps

1: 617 mg / 3-(diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one; DIPEA / tetrahydrofuran / 0 - 20 °C

2: 100 percent / aq. LiOH / tetrahydrofuran / 1 h / 20 °C

3: 92 percent / 3-(diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one; DIPEA / tetrahydrofuran / 48 h / 20 °C

4: 77 percent / EDCI; DMAP / CH₂Cl₂ / 20 °C

With dmap; lithium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja067648h

Reference yield:

: 940301-21-3
Boc-D-Leu-L-Leu-L-HyPhe-OMe

: 940301-24-6
Boc-D-Leu-L-Leu-L-threo-O-[Fmoc-L-Ser(OtBu)]-HyPhe-L-HyLeu(OTBS)-L-Leu-OAll

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / aq. LiOH / tetrahydrofuran / 1 h / 20 °C

2: 92 percent / 3-(diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one; DIPEA / tetrahydrofuran / 48 h / 20 °C

3: 77 percent / EDCI; DMAP / CH₂Cl₂ / 20 °C

With dmap; lithium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja067648h