tert-butyl (4E)-5-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3-hydroxy-4-pentenoate

Base Information

Chemical Name:tert-butyl (4E)-5-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3-hydroxy-4-pentenoate
CAS No.:910867-09-3
Molecular Formula:C₂₄H₃₂FN₃O₅S
Molecular Weight:493.6
Hs Code.:

Synonyms:tert-butyl (4E)-5-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3-hydroxy-4-pentenoate

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Chemical Property of tert-butyl (4E)-5-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3-hydroxy-4-pentenoate

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Technology Process of tert-butyl (4E)-5-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3-hydroxy-4-pentenoate

There total 1 articles about tert-butyl (4E)-5-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3-hydroxy-4-pentenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 890028-66-7
(E)-N-[4-(4-fluorophenyl)-6-isopropyl-5-(3-oxoprop-1-en-1-yl)pyrimidin-2-yl]-N-methyl methanesulfoneamide

: 910867-09-3
tert-butyl (4E)-5-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3-hydroxy-4-pentenoate

Guidance literature:: acetic acid tert-butyl ester; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -65 - 10 ℃; for 2.16667h;

(E)-N-[4-(4-fluorophenyl)-6-isopropyl-5-(3-oxoprop-1-en-1-yl)pyrimidin-2-yl]-N-methyl methanesulfoneamide; In tetrahydrofuran; hexane; at -65 - -5 ℃; for 1.75h;

With acetic acid; In tetrahydrofuran; hexane; for 0.166667h;

Reference yield:

: 910867-09-3
tert-butyl (4E)-5-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3-hydroxy-4-pentenoate

: 910867-10-6
(4E)-5-{4-(4-Fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)-pyrimidin-5-yl}-3-hydroxy-4-pentenoic acid

Guidance literature:: tert-butyl (4E)-5-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3-hydroxy-4-pentenoate; With methanol; sodium hydroxide; water; at 27 - 29 ℃; for 6 - 10h; Heating / reflux;

In water; pH=3 - 4; Acidic conditions;