(4E)-5-{4-(4-Fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)-pyrimidin-5-yl}-3-hydroxy-4-pentenoic acid

Base Information

Chemical Name:(4E)-5-{4-(4-Fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)-pyrimidin-5-yl}-3-hydroxy-4-pentenoic acid
CAS No.:910867-10-6
Molecular Formula:C₂₀H₂₄FN₃O₅S
Molecular Weight:437.492
Hs Code.:

Synonyms:(4E)-5-{4-(4-Fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)-pyrimidin-5-yl}-3-hydroxy-4-pentenoic acid

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Chemical Property of (4E)-5-{4-(4-Fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)-pyrimidin-5-yl}-3-hydroxy-4-pentenoic acid

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Technology Process of (4E)-5-{4-(4-Fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)-pyrimidin-5-yl}-3-hydroxy-4-pentenoic acid

There total 3 articles about (4E)-5-{4-(4-Fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)-pyrimidin-5-yl}-3-hydroxy-4-pentenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (3S)-5-[4-(4-fluorophenyl)-6-isopropyl-2-(n-methyl-n-methylsulfonylamino)pyrimidin-5-yl]-3-hydroxy-4-pentenoic acid (1S)-2-hydroxy-1,2,2-triphenylethyl ester

: 910867-10-6
(4E)-5-{4-(4-Fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)-pyrimidin-5-yl}-3-hydroxy-4-pentenoic acid

Guidance literature:: (3S)-5-[4-(4-fluorophenyl)-6-isopropyl-2-(n-methyl-n-methylsulfonylamino)pyrimidin-5-yl]-3-hydroxy-4-pentenoic acid (1S)-2-hydroxy-1,2,2-triphenylethyl ester; With sodium hydroxide; water; In tetrahydrofuran; methanol; at 25 - 30 ℃; for 0.5h;

With hydrogenchloride; In water; at 25 - 30 ℃; pH=3 - 4;

Reference yield:

: 910867-09-3
tert-butyl (4E)-5-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3-hydroxy-4-pentenoate

: 910867-10-6
(4E)-5-{4-(4-Fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)-pyrimidin-5-yl}-3-hydroxy-4-pentenoic acid

Guidance literature:: tert-butyl (4E)-5-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3-hydroxy-4-pentenoate; With methanol; sodium hydroxide; water; at 27 - 29 ℃; for 6 - 10h; Heating / reflux;

In water; pH=3 - 4; Acidic conditions;

Reference yield:

: 912337-60-1
methyl (4E)-5-{4-(4-flurophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3-hydroxy-4-pentenoate

: 910867-10-6
(4E)-5-{4-(4-Fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)-pyrimidin-5-yl}-3-hydroxy-4-pentenoic acid

Guidance literature:: methyl (4E)-5-{4-(4-flurophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3-hydroxy-4-pentenoate; With methanol; sodium hydroxide; water; at 27 - 29 ℃; for 1 - 2h;

In water; pH=3 - 4; Product distribution / selectivity; Acidic conditions;