3-fluoro-4-(6-methoxy-7-(3-(piperidin-1-yl)propoxy)-quinolin-4-yloxy)benzaldehyde

Base Information

Chemical Name:3-fluoro-4-(6-methoxy-7-(3-(piperidin-1-yl)propoxy)-quinolin-4-yloxy)benzaldehyde
CAS No.:1428788-22-0
Molecular Formula:C₂₅H₂₇FN₂O₄
Molecular Weight:438.499
Hs Code.:

Synonyms:3-fluoro-4-(6-methoxy-7-(3-(piperidin-1-yl)propoxy)-quinolin-4-yloxy)benzaldehyde

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Chemical Property of 3-fluoro-4-(6-methoxy-7-(3-(piperidin-1-yl)propoxy)-quinolin-4-yloxy)benzaldehyde

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Technology Process of 3-fluoro-4-(6-methoxy-7-(3-(piperidin-1-yl)propoxy)-quinolin-4-yloxy)benzaldehyde

There total 10 articles about 3-fluoro-4-(6-methoxy-7-(3-(piperidin-1-yl)propoxy)-quinolin-4-yloxy)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.6%

: 1428788-17-3,205448-56-2
6-(methoxy)-7-(3-(1-pyrrolidinyl)propoxy)-4-(1H)quinolinone

: 405-05-0
3-fluoro-4-hydroxybenzaldehyde

: 1428788-22-0
3-fluoro-4-(6-methoxy-7-(3-(piperidin-1-yl)propoxy)-quinolin-4-yloxy)benzaldehyde

Guidance literature:: In chlorobenzene; at 140 ℃; for 23h;

Reference yield: 41.9%

: 861881-05-2
4-chloro-6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinoline

: 405-05-0
3-fluoro-4-hydroxybenzaldehyde

: 1428788-22-0
3-fluoro-4-(6-methoxy-7-(3-(piperidin-1-yl)propoxy)-quinolin-4-yloxy)benzaldehyde

Guidance literature:: In chlorobenzene; for 17h; Reflux;
DOI:10.1002/ardp.201300087

Reference yield:

: 498-02-2
1-(3-methoxy-4-hydroxyphenyl)ethanone

: 1428788-22-0
3-fluoro-4-(6-methoxy-7-(3-(piperidin-1-yl)propoxy)-quinolin-4-yloxy)benzaldehyde

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 20 °C

2: nitric acid / dichloromethane / 2 h / -10 °C

3: toluene / 110 °C

4: iron; acetic acid / 2 h / 40 - 80 °C

5: acetonitrile / 8 h / 25 - 85 °C

6: trichlorophosphate / acetonitrile / 6 h / Reflux

7: chlorobenzene / 17 h / Reflux

With nitric acid; iron; potassium carbonate; acetic acid; trichlorophosphate; In dichloromethane; N,N-dimethyl-formamide; chlorobenzene; toluene; acetonitrile;
DOI:10.1002/ardp.201300087