3-fluoro-4-(6-methoxy-7-(3-(piperidin-1-yl)propoxy)-quinolin-4-yloxy)benzaldehyde

Base Information

• Chemical Name: 3-fluoro-4-(6-methoxy-7-(3-(piperidin-1-yl)propoxy)-quinolin-4-yloxy)benzaldehyde
• CAS No.: 1428788-22-0
• Molecular Formula: C₂₅H₂₇FN₂O₄
• Molecular Weight: 438.499
• Mol file: 1428788-22-0.mol

Synonyms:3-fluoro-4-(6-methoxy-7-(3-(piperidin-1-yl)propoxy)-quinolin-4-yloxy)benzaldehyde

Chemical Property of 3-fluoro-4-(6-methoxy-7-(3-(piperidin-1-yl)propoxy)-quinolin-4-yloxy)benzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-fluoro-4-(6-methoxy-7-(3-(piperidin-1-yl)propoxy)-quinolin-4-yloxy)benzaldehyde

There total 10 articles about 3-fluoro-4-(6-methoxy-7-(3-(piperidin-1-yl)propoxy)-quinolin-4-yloxy)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.6%

6-(methoxy)-7-(3-(1-pyrrolidinyl)propoxy)-4-(1H)quinolinone (1428788-17-3,205448-56-2) + 3-fluoro-4-hydroxybenzaldehyde (405-05-0) → 3-fluoro-4-(6-methoxy-7-(3-(piperidin-1-yl)propoxy)-quinolin-4-yloxy)benzaldehyde (1428788-22-0)

Guidance literature:

In chlorobenzene; at 140 ℃; for 23h;

Reference yield: 41.9%

4-chloro-6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinoline (861881-05-2) + 3-fluoro-4-hydroxybenzaldehyde (405-05-0) → 3-fluoro-4-(6-methoxy-7-(3-(piperidin-1-yl)propoxy)-quinolin-4-yloxy)benzaldehyde (1428788-22-0)

Guidance literature:

In chlorobenzene; for 17h; Reflux;

DOI:10.1002/ardp.201300087

Reference yield:

1-(3-methoxy-4-hydroxyphenyl)ethanone (498-02-2) → 3-fluoro-4-(6-methoxy-7-(3-(piperidin-1-yl)propoxy)-quinolin-4-yloxy)benzaldehyde (1428788-22-0)

Guidance literature:

Multi-step reaction with 7 steps

1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 20 °C

2: nitric acid / dichloromethane / 2 h / -10 °C

3: toluene / 110 °C

4: iron; acetic acid / 2 h / 40 - 80 °C

5: acetonitrile / 8 h / 25 - 85 °C

6: trichlorophosphate / acetonitrile / 6 h / Reflux

7: chlorobenzene / 17 h / Reflux

With nitric acid; iron; potassium carbonate; acetic acid; trichlorophosphate; In dichloromethane; N,N-dimethyl-formamide; chlorobenzene; toluene; acetonitrile;

DOI:10.1002/ardp.201300087

upstream raw materials:

6-methyloxy-7-(4-(3-chloropropoxy))-4-4-hydroxyquinoline

6-methyloxy-7-(4-(3-(piperidin-1-yl)propoxy))-4-quiolinol

4-chloro-6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinoline

3-fluoro-4-hydroxybenzaldehyde

Downstream raw materials:

(E)-N⁴-(2-fluorophenyl)-N¹-(3-fluoro-4-(6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinoline-4-yloxy)benzylidene)semicarbazide