(±)-4-deuterio-4-phenyltetrahydro-1,2,3-oxathiazine 2,2-dioxide

Base Information

• Chemical Name: (±)-4-deuterio-4-phenyltetrahydro-1,2,3-oxathiazine 2,2-dioxide
• CAS No.: 1151967-81-5
• Molecular Formula: C₉H₁₁NO₃S
• Molecular Weight: 214.249
• Mol file: 1151967-81-5.mol

Synonyms:(±)-4-deuterio-4-phenyltetrahydro-1,2,3-oxathiazine 2,2-dioxide

Chemical Property of (±)-4-deuterio-4-phenyltetrahydro-1,2,3-oxathiazine 2,2-dioxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (±)-4-deuterio-4-phenyltetrahydro-1,2,3-oxathiazine 2,2-dioxide

There total 7 articles about (±)-4-deuterio-4-phenyltetrahydro-1,2,3-oxathiazine 2,2-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(±)-3-deuterio-3-phenylprop-1-yl sulfamate (1151967-80-4) → (±)-4-deuterio-4-phenyltetrahydro-1,2,3-oxathiazine 2,2-dioxide (1151967-81-5) + (+/-)-4-phenyl-tetrahydro-1,2,3-oxathiazine-2,2-dioxide (355145-63-0)

Guidance literature:

With silver hexafluoroantimonate; iron(III) phthalocyanine chloride; bis(tertbutylcarbonyloxy)iodobenzene; In toluene; acetonitrile; at 20 ℃; for 6h; chemoselective reaction; Inert atmosphere;

DOI:10.1021/ja211600g

Reference yield:

(±)-3-phenylpropyl-3,3-d2 sulfamate + 3-phenylpropyl sulfamate (136199-49-0) → C9H10(2)HNO3S (1340519-23-4) + (±)-4-deuterio-4-phenyltetrahydro-1,2,3-oxathiazine 2,2-dioxide (1151967-81-5) + C9H9(2)H2NO3S + (+/-)-4-phenyl-tetrahydro-1,2,3-oxathiazine-2,2-dioxide (355145-63-0)

Guidance literature:

With silver hexafluoroantimonate; bis(tertbutylcarbonyloxy)iodobenzene; [Mn(^tBuPc)]Cl; In acetonitrile; benzene;

Reference yield:

(±)-3-phenylpropyl-3,3-d2 sulfamate → (±)-4-deuterio-4-phenyltetrahydro-1,2,3-oxathiazine 2,2-dioxide (1151967-81-5)

Guidance literature:

With silver hexafluoroantimonate; manganese(III) tetra-4-tert-butylphthalocyanine chloride; bis(tertbutylcarbonyloxy)iodobenzene; In acetonitrile; benzene; at 20 ℃; Reagent/catalyst; Molecular sieve;

DOI:10.1038/nchem.2366

upstream raw materials:

(±)-3-deuterio-3-phenylprop-1-yl sulfamate

(+/-)-3-deuterio-3-phenylpropan-1-ol

3-phenylpropyl sulfamate