5,6-dibenzyloxy-7-(2-morpholin-4-yl-ethoxy)-flavone

Base Information

• Chemical Name: 5,6-dibenzyloxy-7-(2-morpholin-4-yl-ethoxy)-flavone
• CAS No.: 1345982-14-0
• Molecular Formula: C₃₅H₃₃NO₆
• Molecular Weight: 563.65
• Mol file: 1345982-14-0.mol

Synonyms:5,6-dibenzyloxy-7-(2-morpholin-4-yl-ethoxy)-flavone

Chemical Property of 5,6-dibenzyloxy-7-(2-morpholin-4-yl-ethoxy)-flavone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5,6-dibenzyloxy-7-(2-morpholin-4-yl-ethoxy)-flavone

There total 6 articles about 5,6-dibenzyloxy-7-(2-morpholin-4-yl-ethoxy)-flavone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.6%

5,6-bis(benzyloxy)-7-hydroxy-2-phenyl-4H-1-benzopyran-4-one (199446-39-4) + 4-(2-chloroethyl)morpholine hydrochride (3647-69-6) → 5,6-dibenzyloxy-7-(2-morpholin-4-yl-ethoxy)-flavone (1345982-14-0)

Guidance literature:

With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; acetone; for 24h; Reflux;

DOI:10.1039/c1ob06094e

Reference yield:

4-oxo-2-phenyl-7-(prop-2-en-1-yloxy)-4H-1-benzopyran-5,6-diyl diacetate (944830-41-5) → 5,6-dibenzyloxy-7-(2-morpholin-4-yl-ethoxy)-flavone (1345982-14-0)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogenchloride / ethanol / Reflux

2: potassium carbonate / acetone / 24 h / Reflux

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 0.08 h / 20 °C

4: potassium carbonate; potassium iodide / N,N-dimethyl-formamide; acetone / 24 h / Reflux

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; potassium iodide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetone;

DOI:10.1039/c1ob06094e

Reference yield:

5,6-dihydroxy-2-phenyl-7-(prop-2-en-1-yloxy)-4H-1-benzopyran-4-one (944830-42-6) → 5,6-dibenzyloxy-7-(2-morpholin-4-yl-ethoxy)-flavone (1345982-14-0)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetone / 24 h / Reflux

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 0.08 h / 20 °C

3: potassium carbonate; potassium iodide / N,N-dimethyl-formamide; acetone / 24 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; potassium iodide; In tetrahydrofuran; N,N-dimethyl-formamide; acetone;

DOI:10.1039/c1ob06094e

upstream raw materials:

5,6-bis(benzyloxy)-2-phenyl-7-(prop-2-en-1-yloxy)-4H-1-benzopyran-4-one

5,6-bis(benzyloxy)-7-hydroxy-2-phenyl-4H-1-benzopyran-4-one

4-(2-chloroethyl)morpholine hydrochride

4-oxo-2-phenyl-7-(prop-2-en-1-yloxy)-4H-1-benzopyran-5,6-diyl diacetate

Downstream raw materials:

5,6-dihydroxy-7-(2-morpholin-4-yl-ethoxy)-flavone

Refernces