199446-39-4

Upstream product

• 944830-44-8 5,6-bis(benzyloxy)-2-phenyl-7-(prop-2-en-1-yloxy)-4H-1-benzopyran-4-one 
• 944830-41-5 4-oxo-2-phenyl-7-(prop-2-en-1-yloxy)-4H-1-benzopyran-5,6-diyl diacetate 
• 944830-42-6 5,6-dihydroxy-2-phenyl-7-(prop-2-en-1-yloxy)-4H-1-benzopyran-4-one 
• 491-67-8 5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one 
• 67047-05-6 4-oxo-2-phenyl-4H-1-benzopyran-5,6,7-triyl triacetate 

Downstream Products

• 1345982-15-1 5,6-dibenzyloxy-7-(2-piperidin-1-yl-ethoxy)-flavone 
• 1272971-82-0 5,6-dihydroxy-7-(2-piperidin-1-yl-ethoxy)-flavone 
• 944830-45-9 5,6-dibenzyloxy-7-hexyloxy-flavone 
• 944830-46-0 5,6-dihydroxy-7-hexyloxy-flavone 
• 1345982-14-0 5,6-dibenzyloxy-7-(2-morpholin-4-yl-ethoxy)-flavone 
• 1040140-61-1 5,6-dihydroxy-7-(2-morpholin-4-yl-ethoxy)-flavone 
• 1357354-98-3 5,6-bis(benzyloxy)-7-(2-hydroxyethoxy)-2-phenyl-4H-1-benzopyran-4-one 

Relevant academic research and scientific papers

Novel synthetic baicalein derivatives caused apoptosis and activated AMP-activated protein kinase in human tumor cells

Studies on the anti-proliferative activities of novel baicalein derivatives demonstrated that compounds 8 and 9 were able to activate AMPK by enhancing the levels of phosphorylated AMPKα, and showed more potent anti-proliferative effects than baicalein an

Synthesis of ring A-modified baicalein derivatives

Baicalein, an important active constituent of the traditional Chinese herb Scutellaria baicalensis, exhibited antitumor activity and inhibitory activity against P-gp 170. The syntheses of 25 baicalein derivatives, 2-26 (Table), are described here (Scheme