N-cyclohexyl-7-((3,4-dioxo-2-(pyridin-4-ylamino)cyclobut-1-en-1-yl)amino)-N-(2-morpholinoethoxy)heptanamide

Base Information

Chemical Name:N-cyclohexyl-7-((3,4-dioxo-2-(pyridin-4-ylamino)cyclobut-1-en-1-yl)amino)-N-(2-morpholinoethoxy)heptanamide
CAS No.:1202571-54-7
Molecular Formula:C₂₈H₄₁N₅O₅
Molecular Weight:527.664
Hs Code.:

Synonyms:N-cyclohexyl-7-((3,4-dioxo-2-(pyridin-4-ylamino)cyclobut-1-en-1-yl)amino)-N-(2-morpholinoethoxy)heptanamide

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Chemical Property of N-cyclohexyl-7-((3,4-dioxo-2-(pyridin-4-ylamino)cyclobut-1-en-1-yl)amino)-N-(2-morpholinoethoxy)heptanamide

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Technology Process of N-cyclohexyl-7-((3,4-dioxo-2-(pyridin-4-ylamino)cyclobut-1-en-1-yl)amino)-N-(2-morpholinoethoxy)heptanamide

There total 11 articles about N-cyclohexyl-7-((3,4-dioxo-2-(pyridin-4-ylamino)cyclobut-1-en-1-yl)amino)-N-(2-morpholinoethoxy)heptanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1170232-00-4
7-amino-N-cyclohexyl-N-(2-morpholinoethoxy)heptanamide

: 159596-50-6,446861-48-9
3-ethoxy-4-(pyridin-4-ylamino)-cyclobut-3-ene-1,2-dione

: 1202571-54-7
N-cyclohexyl-7-((3,4-dioxo-2-(pyridin-4-ylamino)cyclobut-1-en-1-yl)amino)-N-(2-morpholinoethoxy)heptanamide

Guidance literature:: With triethylamine; In acetonitrile; at 20 ℃;
DOI:10.1021/jm4009949

Reference yield:

: sodium 6-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-hexanesulfonate

: 1202571-54-7
N-cyclohexyl-7-((3,4-dioxo-2-(pyridin-4-ylamino)cyclobut-1-en-1-yl)amino)-N-(2-morpholinoethoxy)heptanamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: phosphorus pentachloride / toluene

2.1: triethylamine / dichloromethane / 2 h / Cooling with ice

2.2: 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / Cooling with ice

3.2: 19 h / 60 °C

4.1: sodium cyanoborohydride / methanol / Cooling with ice

5.1: 4-methyl-morpholine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C

6.1: hydrogenchloride / methanol / 3 h / 20 °C

7.1: triethylamine / acetonitrile / 20 °C

With 4-methyl-morpholine; hydrogenchloride; phosphorus pentachloride; sodium hydride; sodium cyanoborohydride; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;
DOI:10.1021/jm4009949

Reference yield:

: 6633-95-0
6-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)hexanesulfonyl chloride

: 1202571-54-7
N-cyclohexyl-7-((3,4-dioxo-2-(pyridin-4-ylamino)cyclobut-1-en-1-yl)amino)-N-(2-morpholinoethoxy)heptanamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane / 2 h / Cooling with ice

1.2: 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / Cooling with ice

2.2: 19 h / 60 °C

3.1: sodium cyanoborohydride / methanol / Cooling with ice

4.1: 4-methyl-morpholine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C

5.1: hydrogenchloride / methanol / 3 h / 20 °C

6.1: triethylamine / acetonitrile / 20 °C

With 4-methyl-morpholine; hydrogenchloride; sodium hydride; sodium cyanoborohydride; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.1021/jm4009949