2-<4-(5-chloro-2-oxo-1,2-dihydropyrimidin-1-ylmethoxymethyl)benzamido>-3-phenylpropionic acid benzyl ester

Base Information

Chemical Name:2-<4-(5-chloro-2-oxo-1,2-dihydropyrimidin-1-ylmethoxymethyl)benzamido>-3-phenylpropionic acid benzyl ester
CAS No.:146307-11-1
Molecular Formula:C₂₉H₂₆ClN₃O₅
Molecular Weight:531.996
Hs Code.:

Synonyms:2-<4-(5-chloro-2-oxo-1,2-dihydropyrimidin-1-ylmethoxymethyl)benzamido>-3-phenylpropionic acid benzyl ester

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Chemical Property of 2-<4-(5-chloro-2-oxo-1,2-dihydropyrimidin-1-ylmethoxymethyl)benzamido>-3-phenylpropionic acid benzyl ester

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Technology Process of 2-<4-(5-chloro-2-oxo-1,2-dihydropyrimidin-1-ylmethoxymethyl)benzamido>-3-phenylpropionic acid benzyl ester

There total 3 articles about 2-<4-(5-chloro-2-oxo-1,2-dihydropyrimidin-1-ylmethoxymethyl)benzamido>-3-phenylpropionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1738-78-9
L-phenylalanine benzyl ester p-toluene-sulfonic acid salt

: 146307-07-5
4-(5-chloro-2-oxo-1,2-dihydropyrimidin-1-ylmethoxymethyl)benzoyl chloride

: 146307-11-1
2-<4-(5-chloro-2-oxo-1,2-dihydropyrimidin-1-ylmethoxymethyl)benzamido>-3-phenylpropionic acid benzyl ester

Guidance literature:: With triethylamine; In dichloromethane; for 0.333333h; Ambient temperature;
DOI:10.3891/acta.chem.scand.46-1204

Reference yield:

: 88045-96-9
4-(5-chloro-2-oxo-1,2-dihydropyrimidin-1-ylmethoxymethyl)benzoic acid methyl ester

: 146307-11-1
2-<4-(5-chloro-2-oxo-1,2-dihydropyrimidin-1-ylmethoxymethyl)benzamido>-3-phenylpropionic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / 20 nM ammoniumcarbonate buffer (pH 8.4) / 20 h / 37 °C / porcine liver esterase

2: 98 percent / PCl₅ / toluene / 24 h / 20 °C

3: 95 percent / Et₃N / CH₂Cl₂ / 0.33 h / Ambient temperature

With 20 nM ammoniumcarbonate buffer; phosphorus pentachloride; triethylamine; In dichloromethane; toluene;
DOI:10.3891/acta.chem.scand.46-1204

Reference yield:

: 146307-06-4
4-(5-chloro-2-oxo-1,2-dihydropyrimidin-1-ylmethoxymethyl)benzoic acid

: 146307-11-1
2-<4-(5-chloro-2-oxo-1,2-dihydropyrimidin-1-ylmethoxymethyl)benzamido>-3-phenylpropionic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / PCl₅ / toluene / 24 h / 20 °C

2: 95 percent / Et₃N / CH₂Cl₂ / 0.33 h / Ambient temperature

With phosphorus pentachloride; triethylamine; In dichloromethane; toluene;
DOI:10.3891/acta.chem.scand.46-1204