Technology Process of 1-[(dibenzylamino)ethyl]-o-carborane
There total 1 articles about 1-[(dibenzylamino)ethyl]-o-carborane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
n-BuLi;
In
benzene;
under dry inert atm., Schlenk technique; to soln. of carborane was addedBuLi at 25°C, suspn. was stirred for 10 min, then placed in ice bath, ligand was added, soln. stored at 0°C for 1 h, then warmed to room temp., stirred for 12 h; mixt. was filtered, Et2O was added, organic layer was washed with water,dried with anhyd. MgSO4, dried in vac., residue was recrystd. from EtOH at -10°C; elem. anal.;
DOI:10.1021/om020803q
- Guidance literature:
-
With
H3PO4;
In
ethanol;
(N2 or Ar); using Schlenk techniques; dissolving of closo-1-N(benzyl)2(CH2)2-2-H-1,2-C2B9H10 in degassed EtOH, reflux for 12 h; removal of EtOH under reduced pressure, mixing with benzene, addn. of H3PO4, stirring for 15 h at room temp.; decanting via syringe, removal of solvent in vac., washing with petroleum ether, recrystn. from THF/diethyl ether, elem. anal.;
DOI:10.1021/om048979a
- Guidance literature:
-
With
H2; catalyst: Pd/C;
In
ethanol;
under dry inert atm., Schlenk technique; mixt. of carborane, concd. HCl and catalyst under H2 atm. (60 psi) was shaken for 5 h at room temp.; ppt. was filtered, solvent was removed, residue was recrystd. from EtOH at -10°C; elem. anal.;
DOI:10.1021/om020803q
