(S)-1-[3-(Diphenyl-phosphinothioyl)-propionyl]-pyrrolidine-2-carboxylic acid benzylamide

Base Information

Chemical Name:(S)-1-[3-(Diphenyl-phosphinothioyl)-propionyl]-pyrrolidine-2-carboxylic acid benzylamide
CAS No.:354816-54-9
Molecular Formula:C₂₇H₂₉N₂O₂PS
Molecular Weight:476.579
Hs Code.:

Synonyms:(S)-1-[3-(Diphenyl-phosphinothioyl)-propionyl]-pyrrolidine-2-carboxylic acid benzylamide

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Chemical Property of (S)-1-[3-(Diphenyl-phosphinothioyl)-propionyl]-pyrrolidine-2-carboxylic acid benzylamide

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Technology Process of (S)-1-[3-(Diphenyl-phosphinothioyl)-propionyl]-pyrrolidine-2-carboxylic acid benzylamide

There total 3 articles about (S)-1-[3-(Diphenyl-phosphinothioyl)-propionyl]-pyrrolidine-2-carboxylic acid benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 354816-56-1
(S)-1-[3-(Diphenyl-phosphinothioyl)-propionyl]-pyrrolidine-2-carboxylic acid

: 100-46-9
benzylamine

: 354816-54-9
(S)-1-[3-(Diphenyl-phosphinothioyl)-propionyl]-pyrrolidine-2-carboxylic acid benzylamide

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 20 ℃;
DOI:10.1021/ol0161256

Reference yield:

: 354816-53-8
(S)-1-[3-(Diphenyl-phosphinothioyl)-propionyl]-pyrrolidine-2-carboxylic acid methyl ester

: 354816-54-9
(S)-1-[3-(Diphenyl-phosphinothioyl)-propionyl]-pyrrolidine-2-carboxylic acid benzylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / LiOH*H₂O / H₂O; methanol; tetrahydrofuran / 3 h / 0 °C

2: 92 percent / EDC; HOBT / CH₂Cl₂ / 20 °C

With lithium hydroxide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/ol0161256

Reference yield:

: 109602-95-1
3-(diphenylphosphorothioyl)propionic acid

: 354816-54-9
(S)-1-[3-(Diphenyl-phosphinothioyl)-propionyl]-pyrrolidine-2-carboxylic acid benzylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / Et₃N; EDC; HOBT / CH₂Cl₂

2: 74 percent / LiOH*H₂O / H₂O; methanol; tetrahydrofuran / 3 h / 0 °C

3: 92 percent / EDC; HOBT / CH₂Cl₂ / 20 °C

With lithium hydroxide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/ol0161256