5,9-anhydro-1,2,3,4,8-pentadeoxy-8-C-<(4-nitrophenyl)ethynyl>-6-O-(triisopropylsilyl)-D-glycero-D-gulo-deca-1,3-diynitol-1-yl-(1->6-C)-3,7-anhydro-1,2,6-trideoxy-1-C-(4-nitrophenyl)-4-O-(triisopropylsilyl)-D-glycero-D-gulo-oct-1-ynitol

Base Information

Chemical Name:5,9-anhydro-1,2,3,4,8-pentadeoxy-8-C-<(4-nitrophenyl)ethynyl>-6-O-(triisopropylsilyl)-D-glycero-D-gulo-deca-1,3-diynitol-1-yl-(1->6-C)-3,7-anhydro-1,2,6-trideoxy-1-C-(4-nitrophenyl)-4-O-(triisopropylsilyl)-D-glycero-D-gulo-oct-1-ynitol
CAS No.:221189-79-3
Molecular Formula:C₅₀H₆₈N₂O₁₂Si₂
Molecular Weight:945.267
Hs Code.:

5,9-anhydro-1,2,3,4,8-pentadeoxy-8-C-<(4-nitrophenyl)ethynyl>-6-O-(triisopropylsilyl)-D-glycero-D-gulo-deca-1,3-diynitol-1-yl-(1->6-C)-3,7-anhydro-1,2,6-trideoxy-1-C-(4-nitrophenyl)-4-O-(triisopropylsilyl)-D-glycero-D-gulo-oct-1-ynitol

Synonyms:5,9-anhydro-1,2,3,4,8-pentadeoxy-8-C-<(4-nitrophenyl)ethynyl>-6-O-(triisopropylsilyl)-D-glycero-D-gulo-deca-1,3-diynitol-1-yl-(1->6-C)-3,7-anhydro-1,2,6-trideoxy-1-C-(4-nitrophenyl)-4-O-(triisopropylsilyl)-D-glycero-D-gulo-oct-1-ynitol

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Chemical Property of 5,9-anhydro-1,2,3,4,8-pentadeoxy-8-C-<(4-nitrophenyl)ethynyl>-6-O-(triisopropylsilyl)-D-glycero-D-gulo-deca-1,3-diynitol-1-yl-(1->6-C)-3,7-anhydro-1,2,6-trideoxy-1-C-(4-nitrophenyl)-4-O-(triisopropylsilyl)-D-glycero-D-gulo-oct-1-ynitol

Chemical Property:

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Technology Process of 5,9-anhydro-1,2,3,4,8-pentadeoxy-8-C-<(4-nitrophenyl)ethynyl>-6-O-(triisopropylsilyl)-D-glycero-D-gulo-deca-1,3-diynitol-1-yl-(1->6-C)-3,7-anhydro-1,2,6-trideoxy-1-C-(4-nitrophenyl)-4-O-(triisopropylsilyl)-D-glycero-D-gulo-oct-1-ynitol

There total 10 articles about 5,9-anhydro-1,2,3,4,8-pentadeoxy-8-C-<(4-nitrophenyl)ethynyl>-6-O-(triisopropylsilyl)-D-glycero-D-gulo-deca-1,3-diynitol-1-yl-(1->6-C)-3,7-anhydro-1,2,6-trideoxy-1-C-(4-nitrophenyl)-4-O-(triisopropylsilyl)-D-glycero-D-gulo-oct-1-ynitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 221189-64-6
3,7-anhydro-1-C-bromo-1,2,6-trideoxy-6-C-<(4-nitrophenyl)ethynyl>-4-O-(triisopropylsilyl)-D-glycero-D-gulo-oct-1-ynitol

: 221189-70-4
3,7-anhydro-1,2,6-trideoxy-6-C-<<(3-hydroxy-1,1-dimethylpropyl)dimethylsilyl>ethynyl>-1-C-(4-nitrophenyl)-4-O-(triisopropylsilyl)-D-glycero-D-gulo-oct-1-ynitol

: 221189-79-3
5,9-anhydro-1,2,3,4,8-pentadeoxy-8-C-<(4-nitrophenyl)ethynyl>-6-O-(triisopropylsilyl)-D-glycero-D-gulo-deca-1,3-diynitol-1-yl-(1->6-C)-3,7-anhydro-1,2,6-trideoxy-1-C-(4-nitrophenyl)-4-O-(triisopropylsilyl)-D-glycero-D-gulo-oct-1-ynitol

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; 2-isovalerylindane-1,3-dione; lithium iodide; In dimethyl sulfoxide; at 22 ℃; for 14h;
DOI:10.1002/(SICI)1522-2675(19990210)82:2<143::AID-HLCA143>3.0.CO;2-0

Reference yield:

: 636-98-6
p-nitrobenzene iodide

: 221189-79-3
5,9-anhydro-1,2,3,4,8-pentadeoxy-8-C-<(4-nitrophenyl)ethynyl>-6-O-(triisopropylsilyl)-D-glycero-D-gulo-deca-1,3-diynitol-1-yl-(1->6-C)-3,7-anhydro-1,2,6-trideoxy-1-C-(4-nitrophenyl)-4-O-(triisopropylsilyl)-D-glycero-D-gulo-oct-1-ynitol

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / 3)4>, CuI, Et₃N / dimethylsulfoxide / 50 °C

2: 79 percent / MeONa / methanol / 23 h / 22 °C

3: 97 percent / NBS, AgOCOCF₃ / acetone / 3 h / 21 °C

4: 46 percent / 2(dba)3>, CuI, LiI, PMP / dimethylsulfoxide / 14 h / 22 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-Bromosuccinimide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2-isovalerylindane-1,3-dione; sodium methylate; silver trifluoroacetate; triethylamine; lithium iodide; In methanol; dimethyl sulfoxide; acetone;
DOI:10.1002/(SICI)1522-2675(19990210)82:2<143::AID-HLCA143>3.0.CO;2-0

Reference yield:

: 221189-25-9
3,7-anhydro-1,2,6-trideoxy-6-C-<propyl>silyl>ethynyl>-4-O-(triisopropylsilyl)-1-C-(trimethylsilyl)-D-glycero-D-gulo-oct-1-ynitol

: 221189-79-3
5,9-anhydro-1,2,3,4,8-pentadeoxy-8-C-<(4-nitrophenyl)ethynyl>-6-O-(triisopropylsilyl)-D-glycero-D-gulo-deca-1,3-diynitol-1-yl-(1->6-C)-3,7-anhydro-1,2,6-trideoxy-1-C-(4-nitrophenyl)-4-O-(triisopropylsilyl)-D-glycero-D-gulo-oct-1-ynitol

Guidance literature:: Multi-step reaction with 6 steps

1: 97 percent / 0.1N HCl / ethanol / 5.5 h / 50 °C

2: DMSO / 6 h / 60 °C

3: 98 percent / 3)4>, CuI, Et₃N / dimethylsulfoxide / 50 °C

4: 79 percent / MeONa / methanol / 23 h / 22 °C

5: 97 percent / NBS, AgOCOCF₃ / acetone / 3 h / 21 °C

6: 46 percent / 2(dba)3>, CuI, LiI, PMP / dimethylsulfoxide / 14 h / 22 °C

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-Bromosuccinimide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2-isovalerylindane-1,3-dione; sodium methylate; silver trifluoroacetate; dimethyl sulfoxide; triethylamine; lithium iodide; In methanol; ethanol; dimethyl sulfoxide; acetone;
DOI:10.1002/(SICI)1522-2675(19990210)82:2<143::AID-HLCA143>3.0.CO;2-0