Nps-2143

Base Information

Chemical Name:Nps-2143
CAS No.:284035-33-2
Molecular Formula:C₂₄H₂₅ClN₂O₂
Molecular Weight:408.928
Hs Code.:
UNII:Z25PJ77W7V
DSSTox Substance ID:DTXSID10426075
Nikkaji Number:J3.351.731I
Wikipedia:NPS-2143
Wikidata:Q20707377
Pharos Ligand ID:AMQ826YYZXZ6
Metabolomics Workbench ID:149547
ChEMBL ID:CHEMBL180672
Mol file:284035-33-2.mol

Synonyms:N-((R)-2-hydroxy-3-(2-cyano-3-chlorophenoxy)propyl)-1,1-dimethyl-2-(2-nephthyl)ethylamine;N-(2-hydroxy-3-(2-cyano-3-chlorophenoxy)propyl)-1,1-dimethyl-2-(2-nephthyl)ethylamine;NPS 2143;NPS2143

Suppliers and Price of Nps-2143

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
NPS 2143 hydrochloride
10mg
$ 466.00

Tocris
NPS2143 hydrochloride ≥99%(HPLC)
50
$ 908.00

Sigma-Aldrich
NPS2143 hydrochloride ≥98% (HPLC)
5 mg
$ 132.00

Sigma-Aldrich
NPS2143 hydrochloride ≥98% (HPLC)
25 mg
$ 528.00

DC Chemicals
NPS-2143(SB262470A) >98%
1 g
$ 1500.00

Crysdot
NPS-2143 98+%
100mg
$ 420.00

Crysdot
NPS-2143 98+%
50mg
$ 251.00

Crysdot
NPS-2143 98+%
10mg
$ 62.00

Crysdot
NPS-2143 98+%
5mg
$ 43.00

ChemScene
NPS-2143 99.34%
50mg
$ 420.00

Total 40 raw suppliers

Chemical Property of Nps-2143

Chemical Property:

Vapor Pressure:1.17E-15mmHg at 25°C
Refractive Index:1.631
Boiling Point:608.4 °C at 760 mmHg
PKA:13.67±0.20(Predicted)
Flash Point:321.8 °C
PSA：65.28000
Density:1.23 g/cm³
LogP:5.10638
Storage Temp.:Desiccate at RT
Solubility.:≥40.9 mg/mL in DMSO; insoluble in H2O; ≥28.35 mg/mL in EtOH
XLogP3:5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:408.1604557
Heavy Atom Count:29
Complexity:560

Purity/Quality:

99%, ^*data from raw suppliers

NPS 2143 hydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(CC1=CC2=CC=CC=C2C=C1)NCC(COC3=C(C(=CC=C3)Cl)C#N)O
Isomeric SMILES:CC(C)(CC1=CC2=CC=CC=C2C=C1)NC[C@H](COC3=C(C(=CC=C3)Cl)C#N)O
Uses NPS 2143 acts as a potent and selective antagonist for CaSR (Calcium-sensing receptor) which is involved in calcium blood concentration homeostasis.

Technology Process of Nps-2143

There total 22 articles about Nps-2143 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: C₁₀H₈ClNO₂

: 198226-63-0
[2-methyl-1-(naphthalen-2-yl)propan-2-yl]amine

: 284035-33-2
2-Chloro-6-[(S)-3-(1,1-dimethyl-2-naphthalen-2-yl-ethylamino)-2-hydroxy-propoxy]-benzonitrile

Guidance literature:: In ethanol; at 80 ℃; for 72h; Sealed tube;
DOI:10.3390/ijms221810124

Reference yield:

: C₁₀H₈ClNO₂

: 351490-95-4
2-methyl-1-(naphthalen-2-yl)propan-2-amine hydrochloride

: 284035-33-2
2-Chloro-6-[(S)-3-(1,1-dimethyl-2-naphthalen-2-yl-ethylamino)-2-hydroxy-propoxy]-benzonitrile

Guidance literature:: With trialkylamine; In ethanol; for 7h; Reflux;
DOI:10.1038/s41429-019-0177-9

Reference yield:

: 1-(naphthalen-2-ylmethyl)-2,4,6-triphenylpyridin-1-ium tetrafluoroborate

: 284035-33-2
NPS 2143

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / various solvent(s); methanol / 0 °C

1.2: dimethylsulfoxide / 70 °C

2.1: 0.95 g / hydrogen / Pd/C / ethanol

3.1: ethanol / 60 °C

With hydrogen; sodium hydride; palladium on activated charcoal; In methanol; ethanol;
DOI:10.1016/j.tetasy.2005.07.022