Technology Process of 2-((2,6-dichlorophenyl)amino)-N-(6-methoxypyridin-3-yl)-7,7-dimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxamide
There total 11 articles about 2-((2,6-dichlorophenyl)amino)-N-(6-methoxypyridin-3-yl)-7,7-dimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-((2,6-dichlorophenyl)amino)-7,7-dimethyl-7,8-dihydro-1H-benzofuro-[4,5-d]imidazole-5-carboxylic acid;
With
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate;
6-methoxy-pyridin-3-ylamine;
at 20 ℃;
DOI:10.1016/j.bmcl.2017.10.062
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sodium nitrite; trifluoroacetic acid / 2 h / -5 - 0 °C
2.1: sulfuric acid / Reflux
3.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 80 °C
3.2: 9 h / 80 °C
4.1: aluminum (III) chloride / dichloromethane / 18 h / -70 - 20 °C
5.1: iron; hydrogenchloride / water; methanol / 2 h / 0 - 20 °C
6.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 24 h / 20 °C
7.1: sodium hydroxide / water; methanol / 20 - 60 °C
8.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate
8.2: 20 °C
With
hydrogenchloride; aluminum (III) chloride; sulfuric acid; iron; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; sodium nitrite;
In
methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
4.1: |Claisen Rearrangement;
DOI:10.1016/j.bmcl.2017.10.062
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sulfuric acid / Reflux
2.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 80 °C
2.2: 9 h / 80 °C
3.1: aluminum (III) chloride / dichloromethane / 18 h / -70 - 20 °C
4.1: iron; hydrogenchloride / water; methanol / 2 h / 0 - 20 °C
5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 24 h / 20 °C
6.1: sodium hydroxide / water; methanol / 20 - 60 °C
7.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate
7.2: 20 °C
With
hydrogenchloride; aluminum (III) chloride; sulfuric acid; iron; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide;
In
methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
3.1: |Claisen Rearrangement;
DOI:10.1016/j.bmcl.2017.10.062
