N-methoxy-4-methyl-3-[1-oxo-2-[4-(1,2,3,6-tetrahydropyridin-4-yl)benzyl]-1,2-dihydroisoquinolin-6-yl]benzamide

Base Information

Chemical Name:N-methoxy-4-methyl-3-[1-oxo-2-[4-(1,2,3,6-tetrahydropyridin-4-yl)benzyl]-1,2-dihydroisoquinolin-6-yl]benzamide
CAS No.:1070292-71-5
Molecular Formula:C₃₀H₂₉N₃O₃
Molecular Weight:479.579
Hs Code.:

Synonyms:N-methoxy-4-methyl-3-[1-oxo-2-[4-(1,2,3,6-tetrahydropyridin-4-yl)benzyl]-1,2-dihydroisoquinolin-6-yl]benzamide

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Chemical Property of N-methoxy-4-methyl-3-[1-oxo-2-[4-(1,2,3,6-tetrahydropyridin-4-yl)benzyl]-1,2-dihydroisoquinolin-6-yl]benzamide

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Technology Process of N-methoxy-4-methyl-3-[1-oxo-2-[4-(1,2,3,6-tetrahydropyridin-4-yl)benzyl]-1,2-dihydroisoquinolin-6-yl]benzamide

There total 5 articles about N-methoxy-4-methyl-3-[1-oxo-2-[4-(1,2,3,6-tetrahydropyridin-4-yl)benzyl]-1,2-dihydroisoquinolin-6-yl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1070292-67-9
4-{4-[6-(5-methoxycarbonyl-2-methylphenyl)-1-oxo-1H-isoquinolin-2-ylmethyl]phenyl}-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

: 593-56-6
N-methoxylamine hydrochloride

: 1070292-71-5
N-methoxy-4-methyl-3-[1-oxo-2-[4-(1,2,3,6-tetrahydropyridin-4-yl)benzyl]-1,2-dihydroisoquinolin-6-yl]benzamide

Guidance literature:: 4-{4-[6-(5-methoxycarbonyl-2-methylphenyl)-1-oxo-1H-isoquinolin-2-ylmethyl]phenyl}-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester; N-methoxylamine hydrochloride; With isopropylmagnesium chloride; In tetrahydrofuran; at 20 ℃; for 2h;

With water; ammonium chloride; In tetrahydrofuran;

Reference yield:

: 876189-18-3
[5-(methoxycarbonyl)-2-methylphenyl]boronic acid

: 1070292-71-5
N-methoxy-4-methyl-3-[1-oxo-2-[4-(1,2,3,6-tetrahydropyridin-4-yl)benzyl]-1,2-dihydroisoquinolin-6-yl]benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 12 h / 95 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 12 h / 20 °C

3.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 12 h / 75 °C

4.1: isopropylmagnesium chloride / tetrahydrofuran / 2 h / 20 °C

With isopropylmagnesium chloride; sodium hydride; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1070292-54-4
4-methyl-3-(1-oxo-1,2-dihydroisoquinolin-6-yl)benzoic acid methyl ester

: 1070292-71-5
N-methoxy-4-methyl-3-[1-oxo-2-[4-(1,2,3,6-tetrahydropyridin-4-yl)benzyl]-1,2-dihydroisoquinolin-6-yl]benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 12 h / 20 °C

2.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 12 h / 75 °C

3.1: isopropylmagnesium chloride / tetrahydrofuran / 2 h / 20 °C

With isopropylmagnesium chloride; sodium hydride; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; N,N-dimethyl-formamide;