(S)-3-allyloxy-2-tert-butoxycarbonylamino-propionic acid 2-(2-bromo-4-methoxycarbonylaminophenyl)-2-oxo-ethyl ester

Base Information

Chemical Name:(S)-3-allyloxy-2-tert-butoxycarbonylamino-propionic acid 2-(2-bromo-4-methoxycarbonylaminophenyl)-2-oxo-ethyl ester
CAS No.:1329167-61-4
Molecular Formula:C₂₁H₂₇BrN₂O₈
Molecular Weight:515.358
Hs Code.:

Synonyms:(S)-3-allyloxy-2-tert-butoxycarbonylamino-propionic acid 2-(2-bromo-4-methoxycarbonylaminophenyl)-2-oxo-ethyl ester

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Chemical Property of (S)-3-allyloxy-2-tert-butoxycarbonylamino-propionic acid 2-(2-bromo-4-methoxycarbonylaminophenyl)-2-oxo-ethyl ester

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Technology Process of (S)-3-allyloxy-2-tert-butoxycarbonylamino-propionic acid 2-(2-bromo-4-methoxycarbonylaminophenyl)-2-oxo-ethyl ester

There total 7 articles about (S)-3-allyloxy-2-tert-butoxycarbonylamino-propionic acid 2-(2-bromo-4-methoxycarbonylaminophenyl)-2-oxo-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1329167-60-3
(S)-3-allyloxy-2-tert-butoxycarbonylamino-propionic acid 2-(4-amino-2-bromophenyl)-2-oxo-ethyl ester

: 79-22-1
methyl chloroformate

: 1329167-61-4
(S)-3-allyloxy-2-tert-butoxycarbonylamino-propionic acid 2-(2-bromo-4-methoxycarbonylaminophenyl)-2-oxo-ethyl ester

Guidance literature:: With pyridine; In dichloromethane; for 0.166667h; Cooling with ice;

Reference yield:

: 2766-43-0
N-tert-butyloxycarbonyl-L-serine methyl ester

: 1329167-61-4
(S)-3-allyloxy-2-tert-butoxycarbonylamino-propionic acid 2-(2-bromo-4-methoxycarbonylaminophenyl)-2-oxo-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 60 °C / Inert atmosphere

2.1: water; lithium hydroxide / tetrahydrofuran; methanol / 4 h / 20 °C

2.2: pH 3

3.1: potassium carbonate / N,N-dimethyl-formamide / 1.5 h / 20 °C

4.1: hydrogenchloride; iron / ethanol; water / 2 h / 50 °C

5.1: pyridine / dichloromethane / 0.17 h / Cooling with ice

With pyridine; hydrogenchloride; water; iron; potassium carbonate; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 150438-78-1
(2S)-3-allyloxy-2-tert-butoxycarbonylaminopropionic acid

: 1329167-61-4
(S)-3-allyloxy-2-tert-butoxycarbonylamino-propionic acid 2-(2-bromo-4-methoxycarbonylaminophenyl)-2-oxo-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 1.5 h / 20 °C

2: hydrogenchloride; iron / ethanol; water / 2 h / 50 °C

3: pyridine / dichloromethane / 0.17 h / Cooling with ice

With pyridine; hydrogenchloride; iron; potassium carbonate; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;